Design, synthesis and anticancer activity evaluation of new heterocyclic derivatives as PARP inhibitors / (Record no. 74309)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02035cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032411.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191007s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2019.Gh.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ghada Fathy Hussein Elmasry |
| 245 10 - TITLE STATEMENT | |
| Title | Design, synthesis and anticancer activity evaluation of new heterocyclic derivatives as PARP inhibitors / |
| Statement of responsibility, etc. | Ghada Fathy Hussein Elmasry ; Supervised Samir Mohamed Elmoghazy , Fadi Mohsen Awadallah , Enayat Ebrahim Aly |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم و تشييد بعض المشتقات الحلقية الغير متجانسة كمضادات للسرطان من خلال تثبيط انزيم بارب |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ghada Fathy Hussein Elmasry , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 110 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This work deals with the design and synthesis of some novel pyrido[2,3-d]pyridazinone derivatives; VIIIa-g, IXa,b, Xa-d and XIa-g as PARP-1 inhibitors. Molecular modeling techniques were used to support the design. The twenty newly synthesized compounds were evaluated for their ability to inhibit PARP-1. The in vitro cytotoxic activity of the target compounds was also performed at National Cancer Institute, NCI, Maryland, USA against sixty cell lines. Computational ADME study was conducted to ensure that the most active compounds have proper pharmacokinetic and drug-likeness properties |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Olaparib |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PARP-1 inhibitors |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyridopyridazinones |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Enayat Ebrahim Aly , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fadi Mohsen Awadallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samir Mohamed Elmoghazy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2019.Gh.D | 01010110079512000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2019.Gh.D | 01020110079512000 | 22.09.2023 | CD - Rom | 79512.CD |