A computational based approach for studying synaptic cell Adhesion / (Record no. 74538)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02912cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191015s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.18.02.Ph.D.2019.As.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ashraf Mohamed Hassan Hendam |
| 245 12 - TITLE STATEMENT | |
| Title | A computational based approach for studying synaptic cell Adhesion / |
| Statement of responsibility, etc. | Ashraf Mohamed Hassan Hendam ; Supervised Hesham Ahmed Hefny , Ahmed Farouk Alsadek |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | اسلوب حسابى لدراسة التصاق الخلايا المتشابكة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ashraf Mohamed Hassan Hendam , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 117 Leaves : |
| Other physical details | charts ; |
| Dimensions | 30cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Graduate Studies for Statistical Research - Department of Computer and Information Science |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Central Nervous System is responsible for passing signals from all the body to the brain to process it. Brain consists of neurons which are cells that convey information about the world around us, help us make sense of the world and send commands to our muscles to act. Synaptic cell adhesion is connecting neurons in order to establish a network. Neurexins and Neuroligins proteins are two binding partners which represent the core of the synaptic cell adhesion. Neurexin1 gene is playing an important role in synaptic formation, plasticity and maturity. Studies have reported non-synonymous SNPs in Neurexin1 in some diseases. The current thesis is aiming to apply a computational approach for studying the effects of non-synonymous Single Nucleotide Polymorphisms (SNPs) recoded Neurexin1 in diseases patients. The methodology has been implemented in two steps. The first step aims to identify deleterious SNPs, determine damaged protein features (function, stability) and recognize potential protein regions for future research. The effect on protein function is predicted by PROVEAN, SIFT and PolyPhen-2 tools while protein stability is predicted by MUpro and I-Mutant2.0 tools. Prediction results have identified 2 SNPs to be deleterious by all tools and two additional SNPs have agreement between protein function prediction tools and MUpro from stability tools. Higher deleterious prediction results in the stability tools with the percentages of 72%, 78% than the function tools with 25%, 41% and 47%. Agreement percentage of deleterious prediction between stability tools was 56% while 12.5% in the function tools. The identified regions of Neurexin1 for future research are SP and LNS4 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Molecular Dynamic Simulation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neurexin 1 gene |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Synaptic cell Adhesion |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Farouk Alsadek , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hesham Ahmed Hefny , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.18.02.Ph.D.2019.As.C | 01010110079638000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.18.02.Ph.D.2019.As.C | 01020110079638000 | 22.09.2023 | CD - Rom | 79638.CD |