Synthesis and anticancer activity of certain quinoline and 1,8-naphthyridine derivatives / (Record no. 74913)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02472cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191102s2019 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.04.Ph.D.2019.Mi.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mina Emad Adly Elias Makarious |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis and anticancer activity of certain quinoline and 1,8-naphthyridine derivatives / |
| Statement of responsibility, etc. | Mina Emad Adly Elias Makarious ; Supervised Omneya Mahmoud Khalil , Ehab Mohamed Abdelmoneim Gedawy , Afaf Ali Atia Elmalah |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تشييد و دراسة النشاط المضاد للأورام لبعض مشتقات الكينولين و 8,1-النافثريدين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mina Emad Adly Elias Makarious , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 136 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This thesis includes four chapters. The first chapter is an introduction which includes a survey about topoisomerase enzymes, their inhibitors and the synthesis of quinolines and 1,8-naphthyridine derivatives. The second chapter shows the objectives of the work and the designed schemes required for the preparation of the target compounds. The third chapter includes the theoretical discussion of the experimental work, cytotoxic activity, cell cycle analysis and topoisomerase II{uF061} inhibitory activity. Furthermore, it discusses the molecular modeling for all synthesized compounds and the standard topoisomerase II inhibitor merbarone. The fourth chapter studies the experimental part of this thesis which contains the procedures used for the synthesis of the starting compounds, the target compounds and intermediates as well as the physical properties of the synthesized compounds, elemental analysis and spectral data. In addition, it demonstrates the results and procedures for the cytotoxic activity, cell cycle analysis and topoisomerase II{uF061} inhibitory activity as well as the molecular modeling study |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 1,8-naphthyridine derivatives |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer Activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Certain quinoline |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Afaf Ali Atia Elmalah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ehab Mohamed Abdelmoneim Gedawy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Omneya Mahmoud Khalil , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.04.Ph.D.2019.Mi.S | 01010110079756000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.04.Ph.D.2019.Mi.S | 01020110079756000 | 22.09.2023 | CD - Rom | 79756.CD |