New approaches for the synthesis and cytotoxicity of novel heterocyclic compounds derived from Ý-dicarbonyl and cyanomethylene reagents / (Record no. 75003)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02842cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032431.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191105s2018 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.10.M.Sc.2018.Wa.N |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Waleed Nabeel Saeed Aldarkazali |
| 245 10 - TITLE STATEMENT | |
| Title | New approaches for the synthesis and cytotoxicity of novel heterocyclic compounds derived from Ý-dicarbonyl and cyanomethylene reagents / |
| Statement of responsibility, etc. | Waleed Nabeel Saeed Aldarkazali ; Supervised Rafat M. Mohareb , Naglaa Y. Samy , Nadia Y. Megally Abdo |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | اتجاهات جديدة لتحضير و قياس درجة سمية المركبات الغير متجانسة الحلقة الجديدة المشتقة من كواشف بيتا ثنائى الكربونيل و السيانو ميثيلين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Waleed Nabeel Saeed Aldarkazali , |
| Date of publication, distribution, etc. | 2018 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 162 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The reaction of cyclohexan-1,3-dione (1) with benzaldhyde, 4-chlorobenzaldhyde and 4-methoxy benzaldhyde (2a-c) in ethanol in the presence of catalytic amount of piperidine afforded 2-Arylidencyclohexan-1,3-dione 3a-c. The latter compounds reacted with elemental sulfer and either of malonanitrile (4a) or ethyl cyanoacetate (4b) in 1,4-dioxan in the presence of triethylamine to give tetrahydrobenzo[b]thiophen-5-one derivatives 5a-f. Compounds 5a, b were used for the synthesis of thiophene, thiazole and isoxazale derivatives through their reactions with different chemical reagents. The analytical and spectral data of newly synthesized compounds were consistent with their respective structures. The anti-proliferative activities of the newly synthesized compounds were evaluated against the six cancer cell lines A549, HT-29, MKN-45, U87MG, SMMC-7721 and H460. The most potent compounds toward the cancer cell lines 3a, 3c, 5d, 7c, 11c, 16a, 16c, 17a, 19f, 20a, 21c, 23a and 23c, were further investigated towards the five tyrosine kinases c-kit, FIT-3, VEGFR-2, EGFR and PDGFR. Compounds 3c, 5d, 16c, 17a, 19f and 21c were selected for testing of their inhibition for the Pim-1 kinase due to their anti-proliferation activities against the cancer cell lines and their high activities against the tyrosine kinases |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cyclohexan-1,3-dione |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thiazole |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Thiophene |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Yaha Megally Abdo , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Yousef Samy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rafat Melad Mohareb , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.10.M.Sc.2018.Wa.N | 01010110079742000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.10.M.Sc.2018.Wa.N | 01020110079742000 | 22.09.2023 | CD - Rom | 79742.CD |