Significance of some apoptotic and inflammatory markers in the early diagnosis of Egyptian breast cancer patients / (Record no. 75071)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03550cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032433.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191111s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.01.Ph.D.2019.Sa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Samer Atef Tadros Fahim |
| 245 10 - TITLE STATEMENT | |
| Title | Significance of some apoptotic and inflammatory markers in the early diagnosis of Egyptian breast cancer patients / |
| Statement of responsibility, etc. | Samer Atef Tadros Fahim ; Supervised Tarek M. K. Motawi , Nadia I. Zakhary , Hebatallah A. Darwish |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | أهمية دراسة بعض دلالات الالتهاب و الموت المبرمج للخلايا فى التشخيص المبكر لسرطان الثدى فى المرضى المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Samer Atef Tadros Fahim , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 108 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Breast cancer is one of the most relevant malignancies among women. Early diagnosis and accurate staging of breast cancer is important for the selection of an appropriate therapeutic strategy and achieving a better outcome. This study aimed to explore the significance of some apoptotic and inflammatory serum biomarkers in the early diagnosis and staging of Egyptian breast cancer patients. Moreover, it aimed to explore the potential association between survivin promotor gene (BIRC5) -31G/C single nucleotide polymorphism (SNP) (rs9904341) and its impact on breast cancer risk and serum survivin levels in these patients. A total of 135 female patients with physically and pathologically confirmed breast cancer and 40 unrelated controls as well as 40 patients with benign breast mass were recruited from the early detection unit at the National Cancer Institute, Cairo University. Serum survivin, CEACAM1, resistin and visfatin were measured by ELISA, while genotyping for survivin gene promotor was performed using allelic discrimination probes by qPCR. Elevated serum levels of survivin, CEACAM1, resistin and visfatin were observed in different stages of breast cancer patients when compared with normal controls and benign breast lesions. In addition, there was gradual increment in the serum levels of survivin and visfatin in different stages of breast cancer patients. Also, the minor allele C of -31G/C survivin SNP was more frequent in breast cancer patients (19.3%) compared to the control group (7.5%). Furthermore, subjects with GC+CC genotype were at increased risk of breast cancer compared with the GG genotype, relative to both control and benign groups. Moreover, those patients exhibited higher serum levels of survivin compared to GG genotype. In view of that, the studied biomarkers could be useful in the early diagnosis of breast cancer displaying a pivotal role in its pathogenesis. Additionally, serum visfatin and survivin can be used in staging of breast cancer. Eventually, genetic variation in -31G/C of survivin gene may contribute to the disposition of breast cancer in Egyptian population |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Resistin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Survivin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hebatallah A. Darwish , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia I. Zakhary , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek M. K. Motawi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.01.Ph.D.2019.Sa.S | 01010110079847000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.01.Ph.D.2019.Sa.S | 01020110079847000 | 22.09.2023 | CD - Rom | 79847.CD |