MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03485cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
191111s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.10.05.Ph.D.2019.Kh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Khaled Said Ahmed Hassan |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Pathological and immunohistochemical studies on the protective effect of spirulina platensis against reproductive arsenic toxicity in rats / |
| Statement of responsibility, etc. |
Khaled Said Ahmed Hassan ; Supervised Kawkab Abdelaziz Ahmed , Reda Mohammed Sayed , Hanaa Ali Elhalawany |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسات باثولوجية وهستوكيميائية مناعية على التأثير الوقائى للسبيرولينا بلاتنسيس ضد السمية التناسلية للزرنيخ فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Khaled Said Ahmed Hassan , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
149 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Arsenic (As) is currently one of the most important environmental global contaminants and toxicants, particularly in the developing countries. The aim of this study was to investigate the effect of arsenic (As) on the male and female reproductive organs, liver, kidneys, lungs, heart and brain and to assess the effect of Spirulina platensis (Sp) as an ameliorating agent in the arsenic-induced toxicity and exploring its pathway in protection. 120 male and female albino rats were divided into four equal groups, 30 rats in each group (15 males and 15 females): Control group and three treatment groups that daily received As, Sp and Sp+As respectively, Ten rats (5 males and 5 females) from each group were euthanized monthly during the experimental period (3 months). Results showed that the body weight in male and female rats was significantly reduced in As-treated groups compared to the control one, while the co-treatment with Sp significantly recovered the body weight in comparison with As-treated groups. Arsenic significantly increased serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, malondialdehyde (MDA) and significantly reduced serum glutathione (GSH) activities, testosterone and estradiol in comparison with the control groups. Sp co-treatment significantly recovered AST, ALT, GSH, testosterone and estradiol levels and significantly reduced MDA in comparison to As-treated groups. Histopathologically, testes, uterus, ovaries, liver, kidneys, lungs, heart and brain of As-treated groups showed various degenerative and inflammatory changes which were relieved with the Sp co-treatment. Immunohistochemistry revealed increased apoptosis and explore the role of Nrf2 in the arsenic-induced toxicity. In conclusion, As-induced toxicity in rats could be ameliorated by Spirulina platensis co-administration, this with the expression of nrf2 and pro-apoptotic caspase 3 which indicating that Spirulina platensis is combating the generated oxidative stress in As-induced toxicity in albino rats |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Arsenic |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pathology |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Spirulina platensis |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hanaa Ali Elhalawany , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kawkab Abdelaziz Ahmed , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Reda Mohammed Sayed , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
