Expression of microRNA-205 3p and 5p in basal and squamous cell carcinomas / (Record no. 75216)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02894cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032438.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191116s2019 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.10.Ph.D.2019.Sh.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sharif Mohamed Fouad Elbehairy |
| 245 10 - TITLE STATEMENT | |
| Title | Expression of microRNA-205 3p and 5p in basal and squamous cell carcinomas / |
| Statement of responsibility, etc. | Sharif Mohamed Fouad Elbehairy ; Supervised Moustafa Mahmoud Aboul Ela , Ola Mohamed M. Abu Zied , Khadiga Sayed Sayed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تعبير مادتى الميكرو ار ان ايه (بى3-205 و بى5-205) فى سرطان الخلايا القاعدية و سرطان الخلايا الحرشفية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sharif Mohamed Fouad Elbehairy , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 131 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Dermatology and Venerology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are collectively known as non-melanoma skin cancer (NMSC). NMSC is the most common cancer in humans. MicrorRNAs (miRNA, miR) are short single-stranded post-transcriptional regulatory RNAs that have been shown to play important roles in cell development, differentiation, migration and stress responses, as well as cancer development. miR-205 has been found to be dysregulated in a wide range of tumors in humans. Aim of Work: This study is to verify if miR-205 3p and 5p are involved in the pathogenesis of NMSC. Materials and methods: 21 patients with BCC and 21 patients with SCC were recruited. 21 healthy subjects, that were age and sex matched with patients, were used as control population. Tissue expressions of miR-205 3p and 5p were evaluated in patients and controls using Real Time polymerase chain reaction (PCR) technique. Results: Tissue expressions of miR-205 3p and 5p are significantly higher in BCC and SCC compared to controls with a significantly higher expression of miR-205 3p than the 5p arm in both of BCC and SCC. Moreover, the expressions of both arms are significantly higher in SCC compared to BCC. Conclusions: miR-205 3p and 5p seem to be implicated in the pathogenesis of BCC and SCC with the 3p am contributing more to this oncogenic effect. This oncogenic effect could be through miR-205 3p and 5p targeting and inhibiting tumor suppressor proteins in skin cells |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Basal cell carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA-205 3p |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA-205 5p |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khadiga Sayed Sayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Moustafa Mahmoud Aboul Ela , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ola Mohamed M. Abu Zied , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.10.Ph.D.2019.Sh.E | 01010110079801000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.10.Ph.D.2019.Sh.E | 01020110079801000 | 22.09.2023 | CD - Rom | 79801.CD |