MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02887cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
191119s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.01.Ph.D.2019.Ba.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bassam Mohammed Ali Abdelwahab |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Effect of some agents on testicular functions in a rat model of chronic mild stress-induced depression / |
| Statement of responsibility, etc. |
Bassam Mohammed Ali Abdelwahab ; Supervised Atef Tadros Fahim , Amal Ahmed Abdelfattah , Nermin Abdelhamid Sadik |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
(BIO 3.2.1) تأثير بعض المواد على وظائف الخصية ضد الإكتئاب الناجم عن الإجهاد المزمن فى نموذج للجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Bassam Mohammed Ali Abdelwahab , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
139 , (11) P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Chronic stress occurs in everyday life and may lead to depression. Chronic stress is a major factor contributing to male infertility. Increasing evidence has demonstrated that resveratrol or dimethyl fumarate (DMF) has antioxidant and anti-inflammatory functions. The present study was designed to explore the possible protective effects of resveratrol or DMF against the testicular dysfunction associated with depressive brain in a rat model of chronic unpredictable mild stress (CUMS). Rats were subjected to 8 weeks of CUMS to induce depressive-like symptoms. CUMS-induced depressive-like behaviours in rats were evidenced by increased serum corticosterone levels and decreased serum and hippocampal serotonin levels as well as decreased hippocampal BDNF levels. CUMS significantly reduced sucrose preference and increased immobility time in stressed rats. CUMS exposure significantly decreased and increased expression levels of Ý-catenin and GSK-3Ý, respectively in the hippocampus and testes. Furthermore, CUMS exposure resulted in a significant increase in hippocampal and testicular expression levels of NF-mB, TNF-Ü and IL-1Ý and a significant decrease in Bcl-2 expression levels as well as a significant increase in testicular expression levels of Bax. CUMS caused a significant increase and decrease in levels of MDA and GSH, respectively in the hippocampus and testes as well as a significant decrease in serum total antioxidant capacity levels compared to the control group |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Chronic unpredictable mild stress |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Dimethyl fumarate |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Resveratrol |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Amal Ahmed Abdelfattah , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Atef Tadros Fahim , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nermin Abdelhamid Sadik , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
