MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03061cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191119s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.21.Ph.D.2019.Sh.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shimaa Farouk Abdelrahman Ali |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Evaluation of interleukin 17 gene expression in relation to the therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) in CCl₄- induced rat liver fibrosis / |
| Statement of responsibility, etc. |
Shimaa Farouk Abdelrahman Ali ; Supervised Mohamed Akmal A. Elghor , Salwa Farouk Sabet , Fatma A. Abu Zahra |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
CCl₄ تقييم التعبير الجينى للانترليوكين 17 و علاقته بالتأثير العلاجى للخلايا الجذعية الوسيطة المشتقة من نخاع العظم فى فئران مستحثه للتليف الكبدى بواسطة رابع كلوريد الكربون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shimaa Farouk Abdelrahman Ali , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
181 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) was reported in several animal models of liver fibrosis. Interleukin (IL) 17A, IL6 and STAT3 have been described to play crucial roles in chronic liver injury. However, the modulatory effect of MSCs on these markers was controversial in different diseases. The immunomodulatory role of BM-MSCs on IL17A/IL6/STAT3 was not fully elucidated in liver fibrosis. In the present study, we evaluated the capacity of the BM-MSCs in the modulation of cytokines milieu and signal transducers, based on unique inflammatory genes Il17a and Il17f and their receptors Il17rc and their effect on the IL6/STAT3 pathway in CCl₄- induced liver fibrosis in rats. A single dose of BM-MSCs was administered to the group with induced liver fibrosis, and the genes and proteins of interest were evaluated along six weeks after treatment. Our results showed a significant downregulation of Il17a, Il17ra, il17f and Il17rc genes. In accordance, BM-MSCs administration declined IL17, IL2 and IL6 serum proteins and downregulated IL17A and IL17RA proteins in liver tissue. Interestingly, BM-MSCs downregulated both Stat3 mRNA expression and p-STAT3, while Stat5a gene was downregulated and p-STAT5 protein was elevated. Also P-SMAD3 and TGFÝR2 proteins were downregulated in response to BM-MSCs treatment. Collectively, we suggest that BM-MSCs might play an immunomodulatory role in the treatment of liver fibrosis through downregulation of IL17A affecting IL6/STAT3 signaling pathway |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
BM-MSCs |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
IL17A |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
IL6 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Fatma A. Abu Zahra , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Akmal A. Elghor , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Salwa Farouk Sabet , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
