MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02093cam a2200301 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
191126s2019 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.10.Ph.D.2019.Ba.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bahaa Eldin Mohamed Bakr Mostafa Elzenary |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Synthesis and antitumor evaluation of heterocyclic compounds synthesized from B-diketone and cyanomethylene reagents / |
| Statement of responsibility, etc. |
Bahaa Eldin Mohamed Bakr Mostafa Elzenary ; Supervised Raafat Milad Mohareb |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تحضير و قياس مضاداث الأورام لمركبات حلقية غير متجاًنسة محضرة من بيتا ثنائى الكيتون و الميثيلين النشطة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Bahaa Eldin Mohamed Bakr Mostafa Elzenary , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
171 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The reaction of ethyl benzoyl acetate with malononitrile in an oil bath at 120{u00B0}C gave the condensation product 3. The latter compound underwent a series of heterocyclization to give thiophene, thiazole, pyridine and pyras derivatives. The structures of the synthesized products were established on the basis of analytical and spectral data. The antitumor evaluation of the newly synthesized products against the six cancer cell lines namely human gastric cancer (NUGC and HR), human colon cancer (DLDI), human liver cancer (HA22) and (HEPG2), human breast cancer (MCF), nasopharyngeal carcinoma (HONET) and normal fibroblast cells (w138) indicated that many compounds expressed high inhibition against the cancer cell lines. Compounds 3, 7a, 7e, 11b,13e, 13d, 16a,16b, 18a, 20a and 25b were the most cytotoxie compounds among the tested compouds |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Ethy1 benoylacetate |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pyran |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Thiophene |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Raafat Milad Mohareb , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Samia |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
