A pharmaceutical study on the effect of photodynamic therapy to potentiate the anticancer activity of curcumin- loaded nano-systems on breast cancer cell line / (Record no. 75484)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02838cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191126s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.24.03.M.Sc.2019.Am.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amr Ehab Abdelrazik Kamel |
| 245 12 - TITLE STATEMENT | |
| Title | A pharmaceutical study on the effect of photodynamic therapy to potentiate the anticancer activity of curcumin- loaded nano-systems on breast cancer cell line / |
| Statement of responsibility, etc. | Amr Ehab Abdelrazik Kamel ; Supervised Maha Fadel Mohamed , Dina Louis Nassif |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة ص{u٠٦أأ}دلان{u٠٦أأ}ة على تأث{u٠٦أأ}ر العلاج الضوئى الد{u٠٦أأ}نام{u٠٦أأ}كى لتحف{u٠٦أأ}ز النشاط المضاد للسرطان للكركم المحمل على الأنظمة النانو{u٠٦أأ}ة على خلا{u٠٦أأ}ا سرطان الثدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amr Ehab Abdelrazik Kamel , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 81 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Sciences - Department of Laser Application in Medical Biological |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Curcumin (CUR) is a natural component derived from Curcuma longa L. that is known for its anticancer activity. Some problems limit the pharmaceutical usage of CUR, namely, low solubility, low bioavailability and photodegradation. However, being a photosensitizer, CUR stands as an attractive candidate for photodynamic therapy of cancer that overcomes major side effects associated with chemotherapy. Therefore, in this work, CUR was formulated into Nanostructures Lipid Carriers (NLCs) to enhance CUR cell penetration and effectiveness in cancer treatment. The work followed a 3x4 factorial design of two factors; one with three levels and the other with four levels. The first factor was the solid lipid type, where four solid lipids were used, namely, Peceol, Geleol, Compritol and Precirol. The second factor was the solid lipid to liquid lipid ratio which had three levels: 70:30, 85:15 and 95:5. Olive oil was chosen as the liquid lipid. Tween 80 and Lecithin were used as surfactant and cosurfactant, respectively. The factorial design resulted in 12 CUR-NLCs formulae that were prepared using High Shear Hot Homogenization method. The resulting CUR-NLCs were characterized by determining their particle size, polydispersity index, zeta potential, entrapment efficiency percent, drug loading percent and in vitro drug release |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Curcumin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Curcuminoids |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Louis Nassif , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Fadel Mohamed , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.24.03.M.Sc.2019.Am.P | 01010110080188000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.24.03.M.Sc.2019.Am.P | 01020110080188000 | 22.09.2023 | CD - Rom | 80188.CD |