The possible protective role of grape seeds extract versus folic acid on methotrexate induced liver injury in adult male albino rats / (Record no. 75485)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02850cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032448.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191126s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.16.M.Sc.2019.So.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Somaya Mahmoud Mohammed Balah |
| 245 14 - TITLE STATEMENT | |
| Title | The possible protective role of grape seeds extract versus folic acid on methotrexate induced liver injury in adult male albino rats / |
| Statement of responsibility, etc. | Somaya Mahmoud Mohammed Balah ; Supervised Mohammed Ahmed Abdelhafiz , Dalia Mohammed Elmarakby , Abeer Ibraheem Abdallah Omar |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير الوقائى المحتمل لمستخلص بذور العنب الأحمر ضد حمض الفوليك على إصابة الكبد المستحدثه بعقار الميثوتريكسيت فى ذكور الجرذان المهق |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Somaya Mahmoud Mohammed Balah , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 136 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Histology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Hepatic injury, a common complication of methotrexate (MTX) therapy, is followed by fibrosis. Activated hepatic stellate cells (HSCs) are responsible for such fibrosis. Folic acid (FA) reduces the incidence of MTX-liver toxicity meanwhile natural antioxidants are used without interfering the effectiveness. Aim of work: The study aimed at comparing the possible protective effect of grape seeds extract (GSE) and FA in a rat model of MTX-induced liver injury with a special reference on their influence on HSCs. Materials and methods: Thirty five adult male albino rats were divided into control, MTX, MTX-FA and MTX-GSE groups. Liver sections were stained with H&E, trichrome stain and immunohistochemical staining for Ü-smooth muscle actin (Ü-SMA) and glial fibrillary acidic protein (GFAP). Morphometric measurements of mean area percent of collagen fibers, Ü-SMA immune positive cells and GFAP immune positive cells were taken and statistically analyzed. Results: MTX group revealed marked with significant increase in the mean area percent of collagen, GFAP and Ü-SMA +ve cells. FA and GSE treated groups showed improvement in the hepatic lesions which was more obvious with GSE treatment. Conclusion: GSE had a better protective effect in reducing MTX-induced liver injury than FA |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HSCs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Liver injury |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MTX |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Ibraheem Abdallah Omar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Mohammed Elmarakby , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Ahmed Abdelhafiz , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.16.M.Sc.2019.So.P | 01010110080189000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.16.M.Sc.2019.So.P | 01020110080189000 | 22.09.2023 | CD - Rom | 80189.CD |