MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02977cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
191130s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2019.Sh.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shaymaa Mohammed Abdelrahman Elasmer |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Evaluation of the genetic polymorphism in pre-microRNA-146a (rs2910164) and level of serum tumor necrosis factor alpha in patients with ischemic stroke and their effects on disease prognosis / |
| Statement of responsibility, etc. |
Shaymaa Mohammed Abdelrahman Elasmer ; Supervised Manal Mohamed Kamal , Hanan Helmy Mohammed Elgendy , Radwa Marawan Abdelhalim |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
ومعدل مصل عامل نخر الورم الفا بمرضى السكتة الدماغية وتاثيرهم على تطور المرض a لما قبل ميكروالحمض الريبوزى146 (rs2910164) تقييم ترابط التعدد الشكلى الجينى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shaymaa Mohammed Abdelrahman Elasmer , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
125 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background: Inflammation plays a role in the pathogenesis of atherosclerosis and consequently ischemic stroke. Tumor necrosis factor-Ü (TNF-Ü) initiates a cascade of release of cytokines that increases the expression of adhesion molecules on the vascular endothelium. Moreover, single nucleotide polymorphism in Pre-miR-146a may contribute to susceptibility to ischemic stroke by altering mature miR-146a expression levels. Aim of the work: To investigate the association between the pre-miR-146a C> G (r2910164) polymorphism and serum TNF-Ü among group with ischemic stroke and in a group of unrelated volunteers. Subjects &Methods: This was a case control study on 75 cases with ischemic stroke and 75 sex matched control subjects with age range from 57-65 years. Demographic data and computerized tomography confirmation of ischemic stroke were taken from patients files. All samples were subjected to genomic DNA analysis for pre-miR-146a by real time PCR based method and TNF-Ü measurement by enzyme linked immunosobant assay. Results: The frequency of GG genotype within pre-miR-146a (rs2910164) in ischemic stroke cases was significantly different compared to the control subjects with P = 0.017, OR =3.07, 95%CI (1.2-7.7). A highly statistically significant increase in TNF-Ü level in ischemic stroke subjects when compared to the control group; P <0.001 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Ischemic stroke |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Pre-miR-146a |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Rs2910164 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hanan Helmy Mohammed Elgendy , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal Mohamed Kamal , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Radwa Marawan Abdelhalim , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
