Role of 6-aminonicotinamide in aluminum phosphide poisoning induced experimentally in rats / (Record no. 75557)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02944cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032450.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191130s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.29.M.Sc.2019.He.R |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hebat Allah Muhammad Amal |
| 245 10 - TITLE STATEMENT | |
| Title | Role of 6-aminonicotinamide in aluminum phosphide poisoning induced experimentally in rats / |
| Statement of responsibility, etc. | Hebat Allah Muhammad Amal ; Supervised Amani Nabil Shafik , Amr Maher Galal , George Nazih Bishara Morcos |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دور عقار 6- أمينونيكوتين أميد فى تسمم فوسفيد الألمنيوم المحدث تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hebat Allah Muhammad Amal , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 122 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Aluminum Phosphide poisoning became one of the most popular suicidal method among young adults with very high mortality rates encroaching 100%. No Antidote has been discovered yet and the only way to save the patient is to be on supportive measures that mostly fail to protect the patient. 6-aminonicotinamide has been proposed to be a possible antidote in the view of many case reports suggesting higher survival rates in patients with G6PD deficiency. Methods: Preclinical study was done on 48 male albino rats for a duration of 24 hours. Aluminum Phosphide poisoning (ALP) was induced by single dose of 15 mg/kg of ALP in 1 mL of corn oil orally by gastric gavage. 30 minutes after the induction of ALP poisoning, rats were treated with either 10% Dimethyl sulfoxide (DMSO) alone with single intraperitoneal dose of 1ml/kg or N-Acetylcysteine (N-AC) alone in dose of single intraperitoneal dose of 200 mg/kg or treated with single intraperitoneal dose of 1 mg/kg of 6-aminonicotinamide (6-AN) dissolved in 10% DMSO. Echocardiography was done for 2-hour duration with readings of systolic Blood pressure and Heart rate in the 30th, 60th, 90th and the 120th minute. Blood samples were collected 1 hour after the induction of poisoning to estimate levels of Malondialdehyde (MDA), Reduced glutathione (GSH) and liver enzymes (AST and ALT). Pathological specimens were collected after death or sacrificing the rats of liver, lung and heart. Rats were observed for 24-hour duration for the estimation of survival rate and time |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 6-Aminonicotinamide |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Albino rat |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aluminum Phosphide Poisoning |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amani Nabil Shafik , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amr Maher Galal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | George Nazih Bishara Morcos , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.29.M.Sc.2019.He.R | 01010110080222000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.29.M.Sc.2019.He.R | 01020110080222000 | 22.09.2023 | CD - Rom | 80222.CD |