Serum microRNA-21 and microRNA-155 as biomarkers for bronchial asthma / (Record no. 75614)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03261cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032452.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191202s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.19.Ph.D.2019.Sa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sabrin Mohamed Mohamed Abdelhamed Elkashef |
| 245 10 - TITLE STATEMENT | |
| Title | Serum microRNA-21 and microRNA-155 as biomarkers for bronchial asthma / |
| Statement of responsibility, etc. | Sabrin Mohamed Mohamed Abdelhamed Elkashef ; Supervised Sohair Elattar Ahmad , Marwa Salah Mostafa , Youssef Mohamed Amin Soliman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الحمض النووى الريبوزى المصغر 21 و الحمض النووى الريبوزى المصغر 155 بمصل الدم كمؤشرات حيوية فى الربو الشعبى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sabrin Mohamed Mohamed Abdelhamed Elkashef , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 119 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Bronchial asthma is an airway chronic disease characterized by Th2 inflammatory response and tissue remodeling after exposure to inhaled allergens. MicroRNAs (miRNAs) are short non-coding RNAs that are important regulators of gene expression of different immunological molecules. However, the role of miRNAs, specifically miRNA-21 and miRNA-155, in the regulation of allergic airway inflammation is unexplored. The aim of this study was to compare the serum expression levels of miRNA-21 and miRNA-155 in asthmatic patients with that of healthy controls and to correlate their levels with serum IL-4 levels. The study was conducted on 30 asthmatic patients and 30 healthy individuals who served as the control group. The expression levels of miRNA-21 and miRNA-155 were evaluated in the serum of both groups by quantitative reverse transcription PCR while serum levels of IL-4 were determined using the ELISA technique. Asthmatic patients showed significantly higher serum miRNA-21 (P < 0.001) and miRNA-155 (P < 0.001) expression levels and higher serum IL-4 levels (P < 0.001) compared to the controls. There was a statistically significant positive correlation between the expression levels miRNA-21 and IL4 serum levels in the asthmatic patients (rs = 0.609, P = < 0.001). However, no correlation was detected between the expression levels miRNA-155 and each of IL-4 (rs = 0.278, P = 0.136) and miRNA-21 (rs = 0.188, P = 0.321). MiRNA-21 and miRNA-155 are potential non-invasive biomarkers in asthma diagnosis and response to therapy. The effect of miRNA-21 and miRNA-155 on Th2 response and cytokine production can be mediated by different pathways. Further studies are required to investigate the role of miRNA-21 and miRNA-155 in the pathogenesis of different asthma phenotypes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Asthma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiRNA-21 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pathogenesis of asthma |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Salah Mostafa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sohair Elattar Ahmad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Youssef Mohamed Amin Soliman , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.19.Ph.D.2019.Sa.S | 01010110080030000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.19.Ph.D.2019.Sa.S | 01020110080030000 | 22.09.2023 | CD - Rom | 80030.CD |