MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02651cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
191202s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2019.Ma.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mai Aly Sayed Abdelghaney |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
MicroRNA21 and microRNA 10b in breast cancer in relation to metastatic potential / |
| Statement of responsibility, etc. |
Mai Aly Sayed Abdelghaney ; Supervised Dina Farouk Elgayar , Reham Assem Zeyada , Abdelhamid Hussein Ezzat |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
فى مرضى سرطان الثدى MicroRNA21 and microRNA10b التعبير الجينى الخاص بالاحماض الريبونيوكليك الدقيقه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mai Aly Sayed Abdelghaney , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
157 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background : Breast cancer (BC) is a major cause of cancer-related death worldwide. miRNAs have been demonstrated to play an important role in carcinogenesis either by oncogenic or tumor suppressor function.The aim of the present work : is to study the serum levels of miR-21& miR-10b to evaluate their potential use as biomarkers of BC and to correlate their serum levels with the clinicopathological features to detect the diagnostic potential of these miRNAs in patients with BC.Subjects and Methods : This study was conducted on 70 patients with BC and 20 apparently healthy females used as a control group. They were subjected to routine laboratory investigations and gene expression analysis using quantitative SYBR Green reverse {u2013}transcription Real {u2013}Time polymerase chain reaction.Results : It was found that median levels of fold change of miR-10b and miR-21 were significantly higher (up-regulated) in serum of BC patients compared to the healthy control group (p<0.001) . ROC curve analysis for miR 21 have demonstrated AUC of 0.96 [ 95% CI, 0.928 & 1 ] , with sensitivity 95.7% and specificity 85% ,and AUC of 0.99 [ 95% confidence interval (CI), 0.975&1 ], with sensitivity 97.1 % and specificity 100 % for miR 10b,Conclusions: miR21 and miR10b could be helpful biomarkers in BC diagnosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Breast Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
MicroRNA |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
MiR-21 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Abdelhamid Hussein Ezzat , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dina Farouk Elgayar , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Reham Assem Zeyada , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
