Synthesis of some nitrogenous heterocyclic sulfonamide derivatives as anticancer and radiosensitizing agents / (Record no. 75631)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02745cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032452.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191203s2019 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2019.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Galal Eldin Elgazzar |
| 245 10 - TITLE STATEMENT | |
| Title | Synthesis of some nitrogenous heterocyclic sulfonamide derivatives as anticancer and radiosensitizing agents / |
| Statement of responsibility, etc. | Mostafa Galal Eldin Elgazzar ; Supervised Fatma Abdelfattah Ragab , Helmy Ismail Heiba |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير بعض المركبات غير متجانسة الحلقة التى تحتوى على نواة النيتروجين و مجموعة السلفونميد كمضادات للأورام السرطانية و كمحفزات للأشعاع |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mostafa Galal Eldin Elgazzar , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 159 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In a search for new cytotoxic agents with improved activity and selectivity, certain new N-pyridylsulfonamide derivatives have been synthesized. All the newly synthesized compounds were subjected to in vitro cytotoxic screening against human hepatocellular liver carcinoma cell line (HEPG2). The most potent compounds, as concluded from this screening, were selected to be evaluated for their in-vitro cytotoxic activity in combination with Þ-radiation. The new compounds were docked inside the active site of vascular endothelial growth factor receptor 2 (VEGFR2) kinase enzyme in an attempt to predict their mechanism of action and assayed for their inhibitory activity against VEGFR2. It has been concluded that 7 new synthesized compounds 11a, (5, 6)b and (10-13)b showed higher in-vitro cytotoxic activity against HEPG2 cell line than Sorafenib (IC50 range 0.12- 0.66 æM and IC50 for sorafenib = 1.06 æM), while the 3 newly synthesized compounds 5b, 11b and 12b are nearly equipotent to Sorafenib in decreasing the activity level of VEGFR2 kinase enzyme (IC50 33, 37 and 37 nM respectively and IC50 for sorafenib = 30 nM). Additionally the most 9 potent compounds showed a synergistic effect with radiation in the radiosensitizing evaluation, so the drug dose can be decreased and consequently the toxicity will be also decreased |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyridine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sulfonamide |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Fatma Abdelfattah Ragab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Helmy Ismail Heiba , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2019.Mo.S | 01010110080286000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2019.Mo.S | 01020110080286000 | 22.09.2023 | CD - Rom | 80286.CD |