Prognostic factors in metastatic renal cell carcinoma patients in relation to targeted therapy / (Record no. 75645)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02975cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032453.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191205s2019 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.04.M.Sc.2019.Ma.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Manar Saad Mohamed Ramadan |
| 245 10 - TITLE STATEMENT | |
| Title | Prognostic factors in metastatic renal cell carcinoma patients in relation to targeted therapy / |
| Statement of responsibility, etc. | Manar Saad Mohamed Ramadan ; Supervised Hanan Ezzat Shafik , Ahmed Abdelraheem Alnagar , Nevine Fayez Habashy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | السمات التنبوئية للمرضى المصابين بسرطان الخلايا الكلوية المنتشر و المتعلقة بالعلاج الموجه |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Manar Saad Mohamed Ramadan , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 97 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - National Cancer Institute - Department of Oncology-Medical |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Kidney cancer accounts for 5% and 3% of all adult malignancies in men and women, respectively with renal cell carcinoma (RCC) accounts for {u223C} 80% of all kidney cancers. Several agents targeting the vascular endothelial growth factor (VEGF) pathway or the mammalian target of rapamycin (mTOR) pathway were progressively approved for first-line or later-line use in the treatment of patients with advanced RCC and became the new standard of care. The aim of the study is to clarify the clinical and pathological features of metastatic renal cell carcinoma (RCC) cases and correlate the use of targeted therapy with the outcome and survival. Our study included 73 patients diagnosed and managed at medical oncology department of National cancer institute (NCI), Cairo university and Zagazig University Hospitals with 59 patients received targeted therapy after radical nephrectomy and 14 patients had only radical nephrectomy. The study was approved by the institutional review board (IRB), of NCI, Egypt. The overall response rate (RR) was 39% with the median follow up duration was 22.4 months (Range 1.13-64.2) while the overall disease control rate (DCR) was 79.7%. Median overall survival was 32.6 months while median progression free survival (PFS) was 12.7 months. Patients who received targeted therapy had a significant impact on OS, PFS and RR with sunitinib showed better survival than pazopanib as first line, but didn{u2019}t affect the response. The IMDC prognostic model had a better significant relation with the response and survival than MSKCC model |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metastatic renal cell carcinoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pazopanib |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sunitinib |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Abdelraheem Alnagar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Ezzat Shafik , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Fayez Habashy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.04.M.Sc.2019.Ma.P | 01010110080297000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.04.M.Sc.2019.Ma.P | 01020110080297000 | 22.09.2023 | CD - Rom | 80297.CD |