Designing and evaluation of a live attenuated listeria monocytogenes vaccine for hepatocellular carcinoma / (Record no. 75647)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02732cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032453.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191205s2019 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2019.Al.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alyaa Farouk Ahmed Hessin |
| 245 10 - TITLE STATEMENT | |
| Title | Designing and evaluation of a live attenuated listeria monocytogenes vaccine for hepatocellular carcinoma / |
| Statement of responsibility, etc. | Alyaa Farouk Ahmed Hessin ; Supervised Sanaa A. Kenawy , Nemat Z. Yassin , Nancy E. Freitag |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم بكتيريا ليستريا المستوحدة المضعفة و تقييمها كلقاح لسرطان الخلايا الكبدية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Alyaa Farouk Ahmed Hessin , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 130 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Immunotherapy is a promising and highly effective method of targeting hepatocellular carcinoma cells and improving patient outcomes. There is a continuing need for the development and refinement of current vaccine vehicles to safely target tumors while stimulating robust cell mediated immune responses. The facultative intracellular bacterium listeria monocytogenes has proven to be an effective vehicle for the design of cancer vaccines that stimulate potent and long CD8+T cell responses. Critical facets of its effectiveness relate to the ability of gaining access to the cytosol of infected host cells and deliver tumor associated antigens. The study here describes the development and testing of Listeria monocytogenes xprsA2 xhtrA strains as effective vaccine vehicles for the safe delivery of hepatocellular carcinoma antigens. Recombinant listeria monocytogenes xprsA2 xhtrA was engineered to express alpha fetoprotein antigens designed to elicit immunity against hepatocellular carcinoma cells, and tested in a subcutaneous mouse model together with the previously developed listeria monocytogenes xactA prfA* strain. The current results suggest that listeria monocytogenes xprsA2 xhtrA strains represent a highly attenuated yet effective vaccine vector capable of stimulating immunity against hepatocellular carcinoma cells in vivo |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immunotherapy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Listeria monocytogenes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tumors |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nancy Elezebith Freitag , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nemat Zakria Yassin , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Abdelbaky Kenawy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2019.Al.D | 01010110080299000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2019.Al.D | 01020110080299000 | 22.09.2023 | CD - Rom | 80299.CD |