The possible protective effects of DDP4 (dipeptidylpeptidase-4) inhibitors and pyrrolidine dithiocarbamate in thioacetamide-induced ulcerative colitis in rats / (Record no. 75794)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03133cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032457.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191210s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2019.Be.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Berween Mahmoud Abdelelgawad Elmahmoudy |
| 245 14 - TITLE STATEMENT | |
| Title | The possible protective effects of DDP4 (dipeptidylpeptidase-4) inhibitors and pyrrolidine dithiocarbamate in thioacetamide-induced ulcerative colitis in rats / |
| Statement of responsibility, etc. | Berween Mahmoud Abdelelgawad Elmahmoudy ; Supervised Mohamed Farrag Elyamany , Laila Ahmed Rashed , Mai Ahmed Galal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور الوقائى الممكن لمثبطات دايى بيبتيدال وبيروليدين داى ثايو كربامات فى تقرح القالون المستحدث بالثيواسيتاميد بالجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Berween Mahmoud Abdelelgawad Elmahmoudy , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 191 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Ulcerative colitis (UC) is a disease related to a combination of genetic and environmental factors, associated with overproduction of both ROS and RNSleading to oxidative and nitrosative stress, as well as release of pro-inflammatory cytokines. Methods: The effect of sulfasalzine, pyrrolidine dithiocarbamate (PDTC) and saxagliptin was evaluated in thioacetamide (TAA)-induced UC model in the current study.Animals were treated orally with vehicle, sulfasalazine (500 mg/kg), PDTC (100 mg/kg), and saxagliptin (10 mg/kg) for two weeks,UC was induced by single intrarectal instillation of TAA at day eight. Colon samples were collected to assess colonic content of phosphorylated extraregular signal translated kinases (PERK), mitogen-activated protein kinase (MAPK), cAMP response element-binding protein (CREB), Interleukin (IL)-12, Caspase-3, Ý-defensin, glucagon like peptide (GLP)-1,inducible nitric oxide synthase (iNOS), as well as to perform histopathological investigations. Results:TAA-treated rats experienced increases in colon mass index, ulcerative area, colonic PERK, MAPK, CREB, caspase-3, IL-12,Ý-defensin, iNOS, together with decreases in body weight, colon mass index, ulcerative area and GLP-1 and distortion of colonic architecture, as shown by histopathological examination. PDTC and saxagliptin attenuated the severity of colitis, as demonstrated by decrease in body weight loss, colon mass index, ulcerative area as well as decrease in colonic PERK, MAPK, CREB, caspase-3, IL-12,Ý-defensin and iNOS |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inflammatory mediators |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Oxidative stress |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ulcerative colitis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Laila Ahmed Rashed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Ahmed Galal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Farrag Elyamany , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2019.Be.P | 01010110080380000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2019.Be.P | 01020110080380000 | 22.09.2023 | CD - Rom | 80380.CD |