The possible role of metalloproteinase -9 in the pathogenesis of atherosclerosis and osteoporosis and the potential prophylactic effect of carvedilol and bisphosphonates on both conditions in female albino rats / (Record no. 75927)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03270cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032501.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191216s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.30.Ph.D.2019.Se.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Seham Mohamed Sayed Mostafa |
| 245 14 - TITLE STATEMENT | |
| Title | The possible role of metalloproteinase -9 in the pathogenesis of atherosclerosis and osteoporosis and the potential prophylactic effect of carvedilol and bisphosphonates on both conditions in female albino rats / |
| Statement of responsibility, etc. | Seham Mohamed Sayed Mostafa ; Supervised Maha Mohamed Sabry , Suzanne Albert Naguib , Samaa Samir Kamar |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المحتمل للميتالوبروتيناز-9 فى أليه تطور مرضى تصلب الشرايين وهشاشه العظام والدور الوقائى المحتمل لتأثير الكارفيديلول والبيسفوسفونات علي كلا الحالتين في انثى الفئران البيضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Seham Mohamed Sayed Mostafa , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 248 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Physiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The coincidental occurrence of atherosclerosis and osteoporosis may be independent of age, and may be attributed to common pathophysiologic and molecular mechanisms. Matrix metalloproteinase-9 (MMP-9) has been described in the literature as overexpressed in atherosclerosis models and its activity correlated with increased bone resorption in osteoporosis, and hence may be a key molecule in charge for coupling these two pathologies. Objectives: The present work aimed to study the effects of induction of atherosclerosis as well as osteoporosis on inflammatory markers, dyslipidemia markers, bone turnover markers in addition to MMP-9 expression in an attempt to explore the possible link between the two diseases. Furthermore, the present work aimed to examine whether treatment of one of the two diseases can affect the other. The two drugs of choice were Carvidelol which have a curative role in coronary atherosclerosis via its anti-inflammatory and vasodilator effects, and alendronate which is the most potent inhibitor of bone resorption and used for treatment of osteoporosis. Methods: Eighty adult female albino rats (12 weeks age) were divided into 1) control group: subdivided into1A) fed on standard rat show and housed in standard cages (28x40) with the same cagemates throughout the experiment, 1B) Sham ovariectomized rat with the same housing and feeding circumstances as 1A subgroup. 2) Atherosclerotic group: fed on HFD in combination with chronic mild stress. 3) osteoporotic group :underwent ovariectomy via ventral abdominal transverse incision |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Atherosclerosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Metalloproteinase -9 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Osteoporosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Mohamed Sabry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samaa Samir Kamar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Suzanne Albert Naguib , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.30.Ph.D.2019.Se.P | 01010110080411000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.30.Ph.D.2019.Se.P | 01020110080411000 | 22.09.2023 | CD - Rom | 80411.CD |