Formulation and characterization of an in situ gelling ocular system for treatment of glaucoma / (Record no. 76352)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03153cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032514.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200115s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.08.M.Sc.2019.Sa.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sara Abdelmoniem Abdelbary Marzok |
| 245 10 - TITLE STATEMENT | |
| Title | Formulation and characterization of an in situ gelling ocular system for treatment of glaucoma / |
| Statement of responsibility, etc. | Sara Abdelmoniem Abdelbary Marzok ; Supervised Magdy Ibrahim Mohammed , Abeer Mostafa Khattab |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | صياغة وتوصيف نظام هلامى لعلاج ضغط العين المرتفع |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sara Abdelmoniem Abdelbary Marzok , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 165 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Glaucoma or high intraocular pressure (IOP) is an ocular disease that occurs when the balance between the amounts of the intraocular fluid produced and the amount that drains away is disturbed. This causes high fluid pressure in front of the eye and leads to deterioration of the optic nerve. If the IOP is not well cared and controlled, a progressive visual loss and blindness may occur. Latanoprost, a prostaglandin analogue, is an effective ocular hypotensive agent and has the longest duration of action. Latanoprost is a prodrug, once it was administrated topically, it permeates the cornea where it is enzymetically transformed to the active Latanoprost acid. This active form is released into the interior chamber and reaches the iris-ciliary body where it achieves its therapeutic effect. The mechanism of action of this active acid to reduce the IOP is to increase outflow of aqueous humor through the uveoscleral drainage pathway (uveoscleral drainage refers to the drainage of ocular aqueous humor from the anterior chamber into the anterior chamber angle). It has been reported that less than 7% of Latanoprost really reach the site of action due to its short contact time. Therefore, the application of the Latanoprost drop in the eye many times is required to attain the therapeutic effect of the drug. This could expose the eye to the excessive amount of preservatives which may cause irritation, burning, or dryness of the ocular surface. In the recent years, the pharmaceutical scientist intended to formulate a dosage form that circumvents the eye's protective barriers with no damage of tissues. The popular conventional ocular dosage forms such as eye drops (solution and suspension) have various limitations such as the short residence time, large drainage factor due to the high tear fluid turnover, pulsed dosing of drug and poor bioavailability |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Controlled release |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Latanoprost |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pluronic F127 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Mostafa Khattab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Ibrahim Mohammed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.08.M.Sc.2019.Sa.F | 01010110080603000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.08.M.Sc.2019.Sa.F | 01020110080603000 | 22.09.2023 | CD - Rom | 80603.CD |