Assessment of pregabalin-induced cardiovascular effects in experimental animals : (Record no. 76353)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03245cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032514.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200115s2020 ua dho f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Ze.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Zeinab Mohamed Abdelaziz Ismail Mohamed Awwad |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of pregabalin-induced cardiovascular effects in experimental animals : |
| Remainder of title | Studying the modulating effect of angiotensin 1-7 / |
| Statement of responsibility, etc. | Zeinab Mohamed Abdelaziz Ismail Mohamed Awwad ; Supervised Aiman S. Elkhatib , Mahmoud M. Khattab , Ahmed I. Elmallah |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم الآثار القلبية و الوعائية المحدثة بالبريجابالين فى حيوانات التجارب : |
| Remainder of title | دراسة التأثير المعدل للأنجيوتنسين 1-7 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Zeinab Mohamed Abdelaziz Ismail Mohamed Awwad , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 138 P. : |
| Other physical details | charts , facsimiles , photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Pregabalin (PRG) is highly effective in the treatment of epilepsy, neuropathic pain and anxiety disorders. Despite its potential benefits, PRG administration has been reported to induce or exacerbate heart failure (HF). Overactivation of renin angiotensin system (RAS) plays a pivotal role in HF pathophysiological mechanism. To further emphasize the role of RAS in PRG-induced HF pathological mechanism, the protective potential of diminazene aceturate (DIZE), an angiotensin converting enzyme 2 (ACE2) activator, was investigated. PRG administration induced morphometric, echocardiographic and histopathological deleterious alterations and significantly elevated cardiac angiotensin II (Ang II), angiotensin converting enzyme (ACE) and angiotensin II type 1 receptor (AT1R) levels, while reduced angiotensin 1-7 (Ang 1-7), ACE2 and Mas receptor (MasR) cardiac levels. DIZE co-administration showed prominent protection against PRG-induced cardiac alterations in rats. Downregulation of ACE/Ang II/AT1R and upregulation of ACE2/Ang 1-7/MasR axes were noted in DIZE co-treated rats. These findings showed, for the first time, the detailed cardiac deleterious effects of PRG in rats. Moreover, the current study examined the possible cardioprotective effect of telmisartan (Tel), an AT1R blocker, compared with that of captopril (Cap), an ACE inhibitor, in ameliorating PRG-induced HF in rats by assessing morphometric, echocardiographic and histopathological aspects. Furthermore, the role of RAS modulation by the two drugs in guarding against PRG-induced changes in cardiac Ang 1-7 and Ang II levels, in addition to myocardial expression of ACE2, ACE, MasR and AT1R was investigated |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diminazene aceturate |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Heart failure |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pregabalin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed I. Elmallah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Aiman S. Elkhatib , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud M. Khattab , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Ze.A | 01010110080604000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Ze.A | 01020110080604000 | 22.09.2023 | CD - Rom | 80604.CD |