Studies on the protective effect of ginger extract and ginger nanoparticle on acetaminophen toxicity in rats / (Record no. 76373)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03245cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032515.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200118s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.05.M.Sc.2019.Al.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Alaa Fouad Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Studies on the protective effect of ginger extract and ginger nanoparticle on acetaminophen toxicity in rats / |
| Statement of responsibility, etc. | Alaa Fouad Ali ; Supervised Adel Mohamed Bakeer , Sherein Saied Abdelgayed , Osama Samir Zaky Eltawil |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات باثولوجية على التأثير الوقائى لمستخلص الجنزبيل وجزيئات النانو للجنزبيل على سمية الاسيتامينوفين فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Alaa Fouad Ali , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 126 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Veterinary Medicine - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Acetaminophen (APAP) is widely used analgesics all over the world. However, hepatotoxicity and nephrotoxicity are the most remarkable features of acetaminophen overdose. Ginger is a medicinal plant that has immuno-modulatory, anti-tumorigenic, anti-inflammatory, anti-apoptotic, anti-hyperglycemic, anti-lipidemic and anti-oxidant activities. Recently, ginger extract in form of nanoparticles (NPs) have been investigated in liver protection against alcohol-induced liver damage. We conducted in vivo and in vitro studies to compare between the protective efficacy of ginger extract and ginger nanoparticles(GNPs) against acetaminophen-induced toxicity from histological and biochemical aspects. In vivo study, adult male Sprague Dawley rats were received ginger extract and GNPs orally at dose of 120 mg/kg (3times/week) and acetaminophen at dose of 375mg/kg (1/10LD50) daily for three months. Serum Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) as liver functionality indicator were determined. In addition, kidneys functions were assessed by evaluating urea and uric acid levels in serum. Moreover, oxidative stress at the cell level was evaluated by determining malondialdehyde content (MDA) and catalase enzyme (CAT) activity.Meanwhile, histopathological changes in liver and kidney tissues were observed.The present study indicates that liver and kidney biochemical markers are improved in rat pretreated with ginger extract and ginger nanoparticles as well as the activities of cell oxidative stress are statistically significant diminished. In addition, their histological structure of liver and kidney tissues show very little changes.While rats treated with GNPs demonstrate normal biochemical and oxidative stress marker levels andhistological structure relative to ginger extract treated rat |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acetaminophen |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ginger extract |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ginger nanoparticles |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Osama Samir Zaky Eltawil , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherein Saied Abdelgayed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.05.M.Sc.2019.Al.P | 01010110080576000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.05.M.Sc.2019.Al.P | 01020110080576000 | 22.09.2023 | CD - Rom | 80576.CD |