A study of the possible effects of low dose gamma irradiation and certain agents in an experimental model of hepatic encephalopathy / (Record no. 76383)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03340cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032515.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200119s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Gh.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mahmoud Shafey |
| 245 12 - TITLE STATEMENT | |
| Title | A study of the possible effects of low dose gamma irradiation and certain agents in an experimental model of hepatic encephalopathy / |
| Statement of responsibility, etc. | Ghada Mahmoud Shafey ; Supervised Amina S. Attia , Mona A. Elghazaly , Hala F. Zaki |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة التأثيرات المحتملة للتعرض لجرعة منخفضة من اشعة جاما وبعض المواد فى نموذج تجريبى لاعتلال الدماغ الكبدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ghada Mahmoud Shafey , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 116 P. : |
| Other physical details | charts , facsimile ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Brain affection is a common symptom of liver insufficiency. This study aimed to evaluate the role of low-dose Þ irradiation (LDR) , morin and pramipexole as a potential therapeutic agents in thioacetamide (TAA)-induced hepatic encephalopathy (HE) in rats. Effects of local and whole body gamma irradiation (0.5 Gy) on rat brain/liver were evaluated following the induction of HE by TAA (200 mg/kg/day/for 3 successive days). Serum activities of aspartate transaminase (AST) and alanine transaminase (ALT) as well as serum ammonia level were assessed.The effect of HE on brain was evaluated through the determination of brain contents of each of malondialdehyde (MDA), reduced glutathione (GSH), tumor necrosis factor-alpha (TNF-Ü) and interleukin-1beta (IL-1Ý) as well as glutathione peroxidase (GPx) activity. Moreover, apoptotic and inflammatory changes in brain and liver tissues were assessed together with alpha-smooth muscle actin (Ü-SMA); liver fibrosis marker. Morin is a flavonoid constituent of many herbs and fruits with anti-inflammatory and antioxidant properties. The hepatic/neuronal supportive effects of morin in an experimental rat model were evaluated following the induction of acute hepatic encephalopathy (HE) by thioacetamide. Also, silymarin was used as a reference standard drug. Pramipexole as a symptomatic treatment was evaluated. Results showed correction of the biochemical parameters, an observation that was supported by the results of the immuno-histochemical examinations. Finally, these findings are therefore indicative that LDR and morin could be of value in the treatment of hepatic encephalopathy induced by TAA, through one or more molecular mechanisms.Pramipexole showed no significant effect on inflammatory markers Pramipexole improved TAA-induced effects on brain GSH content and GPx activity while no effect was noted on MDA brain content |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Hepatic encephalopathy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | low dose Þ-irradiation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Morin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amina S. Attia , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala F. Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona A. Elghazaly , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Gh.S | 01010110080654000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Gh.S | 01020110080654000 | 22.09.2023 | CD - Rom | 80654.CD |