Physiological and teratogenic effects of anti-epileptic drug (Pregabalin) on albino rat fetuses / (Record no. 76497)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02633cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032519.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200203s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2019.Sa.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sanaa Abdellatif Sayed |
| 245 10 - TITLE STATEMENT | |
| Title | Physiological and teratogenic effects of anti-epileptic drug (Pregabalin) on albino rat fetuses / |
| Statement of responsibility, etc. | Sanaa Abdellatif Sayed ; Supervised Elsayed Fahim Elsayed , Heba Ali Abdelrahman |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأث{u٠٦أأ}ر الفس{u٠٦أأ}ولوجي والمشوه لعقار البر{u٠٦أأ}جابال{u٠٦أأ}ن المضاد للصرع على أجنة الجرذان الب{u٠٦أأ}ضاء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sanaa Abdellatif Sayed , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 98 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Pregabalin (PGB) [(S)-3-(Aminomethyl)-5-methylhexanoic acid 3-isobutyl GABA], as a new anticonvulsant drug is structurally related to gabapentin. However, it is a novel gamma-aminobutyric acid (GABA) analog which is virtually inactive at GABA receptors. Objective: to assess the histological effects of Pregabalin on albino rat fetuses during the pregnancy period. Twenty pregnant rats (Rattus norvegicus) weighing (190-200) were divided into the two groups. The control group was administered oral dose of distilled water and the treated group was administered oral dose of PGB (0.3 mg/kg) from the 6th day to the 20th day of gestation. At 20th day of gestation the females were sacrificed. Administration of PGB significantly reduced the fetal body weight and crown-rump length in comparison with the control group. Moreover, PGB treatment caused malformations that summarized as severe growth retardation, open eyes and skeletal abnormalities. Examination of fetal liver, kidney and brain of pregnant rats treated with PGB showed histopathological changes. It has been found that gestational usage of PGB may cause fetal risk with intrauterine growth retardation, hepatic injury and nephrotoxicity.The pregnant women should be used PGB if its benefits more than the potential risks |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antepileptic |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Malformation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pregnancy |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Elsayed Fahim Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Ali Abdelrahman , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2019.Sa.P | 01010110080712000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2019.Sa.P | 01020110080712000 | 22.09.2023 | CD - Rom | 80712.CD |