Design and synthesis of histone deacetylase inhibitors (HDACIs) as anticancer agents / (Record no. 76501)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02494cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032519.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200203s2020 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2020.Ma.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Marwa Arafa Ibrahim Abdelaziz |
| 245 10 - TITLE STATEMENT | |
| Title | Design and synthesis of histone deacetylase inhibitors (HDACIs) as anticancer agents / |
| Statement of responsibility, etc. | Marwa Arafa Ibrahim Abdelaziz ; Supervised Samir Mohamed Elmoghazy , Sahar Mahmoud Abouseri , Riham François George |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم و تشييد مثبطات الانزيم هيستون دى-أستيلاز كمضادات للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Marwa Arafa Ibrahim Abdelaziz , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 196 P. : |
| Other physical details | facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In a search for new anticancer candidates, and motivated by the pivotal role of class III histone deacetylase (Sirtuins) in the occurrence and development of a variety of diseases including cancer, in addition to the promising anticancer activity exhibited by SIRT2 inhibitors, it deemed of interest to design and synthesize new series of phenolic azomethine derivatives and 5-arylidene thiazolidinones as novel anticancer SIRT2 inhibitors. In this regards, docking studies were performed to support the implemented design strategies. The synthesized target compounds were subjected to SITR2 enzyme inhibitory assay. Additionally, in vitro cytotoxic activities of the targeted compounds were tested in the NCI-60 human tumor cell line anticancer drug screening program, subsequently their selective cytotoxicity against the lung cancer cell line HOP-92 and the brain cancer cell line SNB-75 was assayed. Furthermore, the most active compounds were then tested for their effect on the cell cycle and apoptotic induction activity, in addition to their growth inhibitory activity against the human normal lung fibroblast cell line WI-38 |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Anticancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Apoptosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sirtuins |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Riham François George , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sahar Mahmoud Abouseri , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samir Mohamed Elmoghazy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2020.Ma.D | 01010110080715000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2020.Ma.D | 01020110080715000 | 22.09.2023 | CD - Rom | 80715.CD |