Molecular association of lncRNA-uc003wbd and lncRNA-AF085935 expression with a genetic variant profile in patients with hepatocellular carcinoma and HBV / (Record no. 76503)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03191cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032519.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200204s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.01.Ph.D.2020.No.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Noha Ali Abdelhameed Mehana |
| 245 10 - TITLE STATEMENT | |
| Title | Molecular association of lncRNA-uc003wbd and lncRNA-AF085935 expression with a genetic variant profile in patients with hepatocellular carcinoma and HBV / |
| Statement of responsibility, etc. | Noha Ali Abdelhameed Mehana ; Supervised Tarek M. Kamal Motawi , Shohda A. Elmaraghy , Dina Sabry Abdelfatah |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | Bبالتحور الجينى فى مرضى سرطان الخلايا الكبدية والتهاب الكبد الوبائى lncRNA-AF085935و IncRNA-uc003wbd الإرتباط الجزيئى بين التعبير الجينى لكل من |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Noha Ali Abdelhameed Mehana , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 104 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Long non coding RNAs (lncRNAs) such as lncRNA-AF085935, lncRNA-uc003wbd, highly upregulated liver cancer (HULC) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) have been involved in pathogenesis of hepatocellular carcinoma (HCC). Single nucleotide polymorphism (SNP) in HULC and MALAT1 has an impact on susceptibility to HCC. However, association between these SNPs and serum lncRNA-AF085935 and lncRNA-uc003wbd levels and their significance in differentiation of HCC from hepatitis B virus (HBV) infected Egyptian patients and the healthy subjects haven{u2019}t been explored yet. In the present study, HULC rs7763881 and MALAT1 rs619586 SNPs were genotyped in 70 HBV-positive HCC,70 HBV patients and 70 healthy controls in Egyptian population and serum levels of lncRNA-AF085935 and lncRNA-uc003wbd of all the participants were investigated by quantitative real-time (qRT) PCR. HULC rs7763881 AC/CC genotype significantly decreased HCC risk. Also, MALAT1 rs619586 AG/GG genotype decreased HCC susceptibility with a borderline significance. Serum lncRNA-AF085935 and lncRNA-uc003wbd levels were higher in HBV-positive HCC and HBV patients compared to controls. ROC analysis distinguished between the three groups and predicted lncRNAs performance in HCC and HBV diagnosis.Serum lncRNA-AF085935 and lncRNA-uc003wbd levels were lower in patients carrying AC/CC genotype of rs7763881 and AG/GG of rs619586 compared with AA genotype. In conclusion, HULC and MALAT1 SNPs are associated with decreased HCC risk in HBV infected Egyptian patients and are correlated with serum lncRNA-AF085935 and lncRNAuc003wbd levels, diagnostic HCC biomarkers |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HULC |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Long noncoding RNAs |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MALAT1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Sabry Abdelfatah , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shohda A. Elmaraghy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek M. Kamal Motawi , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.01.Ph.D.2020.No.M | 01010110080716000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.01.Ph.D.2020.No.M | 01020110080716000 | 22.09.2023 | CD - Rom | 80716.CD |