MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02826cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
200206s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.25.M.Sc.2019.Li.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Lina Abdelhamid Ahmed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Study of some signaling pathways of epithelial- mesenchymal transition during gonadogenesis of albino rat (rattus norvegicus) / |
| Statement of responsibility, etc. |
Lina Abdelhamid Ahmed ; Supervised Saeed Abdelrahman Moustafa , Ibrahim Yehia Abdelkader , Mohamed Ismail |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة بعض إشارات المشارات لعملية تغيرالخلايا الطلائية إلي خلايا وسطية عند تكوين المناسل لجنين الجرذ الأبيض - راتس نورفيكس |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Lina Abdelhamid Ahmed , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
53 P. : |
| Other physical details |
charts ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The epithelial mesenchymal transition (EMT) plays a critical role in normal embryonic development as well as abnormal pathological events such as tumor formation and metastasis. One of these important events that may explain this phenomenon during embryogenesis is the migration of primordial germ cells (PGCs) from hindgut into the genital ridge during gonadogenesis. Yet, more studies are needed to explain the molecular changes underlying the role of EMT during gonadogenesis. Here, we aimed to study the molecular changes of four genes to determine whether the EMT occurs during gonadogenesis. These studied genes are alkaline phosphatase (ALP), as PGCs marker, E-cadherin (CDH1) as epithelial marker,Vimentin (VIM) as mesenchymal marker and signal transducer and activator of transcription 3 (STAT3) as migration regulator and differentiation marker.The results showed a substantial decrease in the expression of ALP by the increase of the embryonic age. The expression of CDH1 is inversely proportional to the expression of VIM during the days of PGCs migration. STAT3 expression related to the time of occurrence of migration and differentiation. Taken together, our findings demonstrated the molecular changes of ALP, PGC, CDH1 and VIM during the process of gonadogenesis. Further studies are warranted to understand other molecular mechanisms associated with gonadogenesis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Epithelial mesenchymal transition (EMT) |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Gonadogenesis |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Primordial germ cells (PGCs) |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ibrahim Yehia Abdelkader , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Ismail , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Saeed Abdelrahman Moustafa , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
