The possible neuroprotective effect of eprosartan and nateglinide in rats with cerebral ischemia- reperfusion injury / (Record no. 76598)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02680cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032522.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200210s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Mo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ibrahim Mohamed Fahmy |
| 245 14 - TITLE STATEMENT | |
| Title | The possible neuroprotective effect of eprosartan and nateglinide in rats with cerebral ischemia- reperfusion injury / |
| Statement of responsibility, etc. | Mohamed Ibrahim Mohamed Fahmy ; Supervised Muhammad Farag Elyamany , Naglaa Assaf , Muhammed Abdullatif |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير الوقائى المحتمل لدوائى إيبروسارتان و ناتيجلينايد على نقص التروية و إعادتها فى مخ الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohamed Ibrahim Mohamed Fahmy , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 192 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Ischemic stroke is a major cause of death and motor disabilities all over the world. It is associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammatory and anti-apoptotic effects. Eprosartan (EPRO) is an angiotensin type 1 receptor (AT1R) antagonist, used in treatment of hypertension which can also block AT1R of the brain and alleviate some of the pathophysiologic basis of stroke.The aim of our study was to elucidate the neuroprotective role of EPRO and NAT in the middle cerebral artery occlusion (MCAO)-induced stroke in rats. Ninety six male rats were divided to 6 groups (n = 16 in each group): the sham-operated group, sham receiving EPRO (60 mg/kg/day, p.o) group, sham receiving NAT (50 mg/kg/day, p.o) group, ischemia/reperfusion (IR) group, IR receiving EPRO group (60 mg/kg/day, p.o) and IR receiving NAT group (50 mg/kg/day, p.o). MCAO caused deficits in the motor functions of the rats with an increase of inflammation and apoptotic biomarkers has been observed in IR rats. Pretreatment with EPRO or NAT preserved some of the rats{u2019} behavioral and motor functions |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Eprosartan |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Inflammation |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Nateglinide |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muhammad Farag Elyamany , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Muhammed Abdullatif , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Assaf , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Mo.P | 01010110080809000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Mo.P | 01020110080809000 | 22.09.2023 | CD - Rom | 80809.CD |