HPV16 as a Predisposing Agent for head and neck squamous cell carcinoma / (Record no. 76639)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03061cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032523.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200212s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.19.Ph.D.2020.No.H |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Noha Mohamed Sayed Ahmed Omar |
| 245 10 - TITLE STATEMENT | |
| Title | HPV16 as a Predisposing Agent for head and neck squamous cell carcinoma / |
| Statement of responsibility, etc. | Noha Mohamed Sayed Ahmed Omar ; Supervised Somaia Abdellatif Eissa , Reham Aly Fahmy , Lamiaa Abdelfattah Madkour |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فيروس الورم الحليمى 16 كعامل مسبب لسرطان الخلايا الحرشفية بالرأس و الرقبة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Noha Mohamed Sayed Ahmed Omar , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 130 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Microbiology and Immunology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Human papillomavirus (HPV) is a causative agent in a subset of head and neck squamous cell carcinomas (HNSCCs). Despite a variety of clinically available tests there is no consensus on which technique is the best for detection of HPV in HNSCCs. Although such field has received great interest within different countries and continents, African and Egyptian populations are not yet well studied within the literature. Aim of the work: To detect the prevalence of HPV16 in HNSSC and correlate the viral prevalence with different cliniopathologic parameters as well as patients{u2019} outcome. Material and Methods: This is a cross sectional analytical study which included 51 cases of HNSCC admitted at the Otorhinolaryngology Department, Faculty of Medicine, Cairo University. HPV16 DNA was determined by polymerase chain reaction (PCR) with type-specific primers, while E6/7 mRNA was detected by real time PCR (RT-PCR) and p16 status was determined by immunohistochemistry (IHC). Results: HPV16 DNA was detected in 52.9% of cases, E6/7 mRNA was detected in 52.9% of cases and p16 was overexpressed in 49% of cases. There was a very good agreement between HPV16 DNA results by PCR and RNA results by RT-PCR (m= 0.843, p-value < 0.001). There was a good agreement between HPV16 DNA results by PCR and p16 IHC results (m= 0.608, p-value < 0.001). Likewise, there was a good agreement between RNA results by RT-PCR and p16 IHC results (m= 0.608, p-value < 0.001). By the end of the study period, 13.7% of patients died. The overall survival of the studied cases was 17.29 months. There was no statistically significant correlation between the overall survival and HPV status |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | DNA |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Head and neck cancers |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HPV16 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lamiaa Abdelfattah Madkour , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reham Aly Fahmy , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Somaia Abdellatif Eissa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.19.Ph.D.2020.No.H | 01010110080789000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.19.Ph.D.2020.No.H | 01020110080789000 | 22.09.2023 | CD - Rom | 80789.CD |