Possible hepatoprotective effects of lycopene and colesevelam against ethinylestradiol-induced cholestasis in rats / (Record no. 76762)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03156cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032527.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200223s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.M.Sc.2020.Ay.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aya Hamada Mohamed Shoeib |
| 245 10 - TITLE STATEMENT | |
| Title | Possible hepatoprotective effects of lycopene and colesevelam against ethinylestradiol-induced cholestasis in rats / |
| Statement of responsibility, etc. | Aya Hamada Mohamed Shoeib ; Supervised Helmy Moawad Sayed Ahmed , Hanan Amin Rizk , Walaa Wadie Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الفاعليات الوقائية المحتملة للكبد لليكوبين والكوليسيفلام ضد توقف العصارة الصفراوية المستحدث بالايثنيل استراديول فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Aya Hamada Mohamed Shoeib , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 106 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Estrogen-induced cholestasis is a pathological condition characterized by impaired bile flow and the accumulation of bile acids in the plasma of susceptible women, either after estrogen administration or in pregnancy. Experimental cholestasis induced by estrogen administration to rodents, mainly 17Ü-ethinylestradiol (EE), causes liver injury through mechanisms including oxidative stress and structural or functional damage of the hepatocyte membrane, due to the detergent properties of bile acids. The present study focused on the elucidation of the potential protective effects of lycopene and colesevalm against estradiol induced cholestasis. Useful effects of antioxidants in cholestasis have been reported in several experimental models. Being a natural antioxidant carotenoid, lycopene is suggested to be one of the most powerful antioxidants. Colesevelam is a bile acid sequestrant, which interrupt the enterohepatic circulation of bile acids by binding with them in the intestine to form an insoluble complex that is excreted in the feces. Silymarin was used as a standard reference hepatoprotective agent. Estradiol administrated subcutaneously (5mg/kg) for 18 days to male rats, caused significant increases in total bile acid (TBA), serum alanine aminotranferase (ALT), aspartate aminotrasnferase (AST),alkaline phosphatase (ALP), gamma glutamyle transferase (GGT), total bilirubin (T.Bil), liver contents of malondialdehyde (MDA), hepatic tumor necrosis factor (TNF)-Ü and myeloperoxidase (MPO) in liver tissue as compared with the control group while significantly decreased total protein ,albumin and reduced glutathione (GSH) content |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antioxidant |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cholestasis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ethinylestradiol |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Amin Rizk , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Helmy Moawad Sayed Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa Wadie Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.M.Sc.2020.Ay.P | 01010110080890000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.M.Sc.2020.Ay.P | 01020110080890000 | 22.09.2023 | CD - Rom | 80890.CD |