Impact of TP53 mutation and angiogenesis on the response to induction therapy in newly diagnosed Egyptian pediatric acute lymphoblastic leukemia patients / (Record no. 76776)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03062cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032527.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200224s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2019.Ma.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mariam Maged Fathy Mohamed Elhaddad |
| 245 10 - TITLE STATEMENT | |
| Title | Impact of TP53 mutation and angiogenesis on the response to induction therapy in newly diagnosed Egyptian pediatric acute lymphoblastic leukemia patients / |
| Statement of responsibility, etc. | Mariam Maged Fathy M. Elhaddad ; Supervised Mahmoud Hassan Fawzy Elguibaly , Alaa Mohamed Elhaddad , Basma Mostafa Elgamal |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | وتولد الاوعية الدموية على الاستجابة للعلاج الاستهلالى فى الاطفال المصريين مرضى سرطان الدم الليمفاوى الحاد TP53 تاثير طفرة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mariam Maged Fathy Mohamed Elhaddad , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 133 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Acute lymphoblastic leukemia (ALL) is a malignant transformation and proliferation of lymphoid progenitor cells in the bone marrow, blood and extramedullary sites. It is the most common leukemia in children. In ALL, TP53 mutations have been poorly investigated, mainly in children. Tumorsuppressor pathways such as TP53 function in part by reducing the angiogenic potential of transformed cells. Limiting angiogenesis by TP53 occurs through the dual action of inhibiting proangiogenic signals and increasing production of angiostatic factors. To our knowledge this issue was poorly investigated in Egypt, Middle East and in international publications. Objective: In this study we investigated the impact of TP53 gene mutation and angiogenesis on the induction of remission in Egyptian children newly diagnosed of having ALL. Patients and methods: This study included 40 de novo Egyptian pediatric ALL patients referred from the pediatric oncology outpatient clinics in NCI-Cairo University in the period between May 2015 to June 2016. Bone marrow aspiration (BMA) and trephine biopsy (BMB) were obtained from all patients at diagnosis. Immunohistochemistry (IHC) will be carried out using anti CD- 34 monoclonal antibodies to study microvascular density (MVD) as marker of angiogenesis and BM aspirates were cultured, harvested and prepared for fluorescent in situ hybridization (FISH) to study TP53. All patients received total 15 induction therapy and were assessed at day 42 (end of phase 2 induction) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Angiogenesis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MVD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TP53 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Alaa Mohamed Elhaddad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Basma Mostafa Elgamal , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud Hassan Fawzy Elguibaly , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Asmaa |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2019.Ma.I | 01010110080870000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2019.Ma.I | 01020110080870000 | 22.09.2023 | CD - Rom | 80870.CD |