Six months clinical and echocardiographic outcome of angiotensin receptor-neprilysin inhibitor LCZ696 therapy in heart failure patients with reduced ejection fraction / (Record no. 76805)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03451cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032529.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200227s2019 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.04.M.Sc.2019.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Samir Mohammed Alsayed Alnims |
| 245 10 - TITLE STATEMENT | |
| Title | Six months clinical and echocardiographic outcome of angiotensin receptor-neprilysin inhibitor LCZ696 therapy in heart failure patients with reduced ejection fraction / |
| Statement of responsibility, etc. | Mohammed Samir Mohammed Alsayed Alnims ; Supervised Magdy Abdelhamid Abdelaziz , Mohamed Abdelmeguid Mahdy , Ahmed Shehata Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى مرضى هبوط عضلة القلب (LCZ696) النتائج الإكلينيكية و بالموجات الصوتية على القلب بعد ستة أشهر من العلاج بمثبط مستقبل الأنجيوتنسين {u٢٠١٣} النيبريلايسين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohammed Samir Mohammed Alsayed Alnims , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 139 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Cardiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The discovery and introduction of Neprilysin inhibitor in treating chronic heart failure (New York heart association class II{u2013}IV) with reduced ejection fraction (HFrEF) is a remarkable landmark in therapy. The clinical outcome of reducing the incidence of death from cardiovascular causes or first hospitalization for worsening heart failure was demonstrated in PARADIGM-HF trial. These benefits may be related to effects on hemodynamics and cardiac remodeling. Objectives: To evaluate the clinical and echocardiographic outcome of Sacubitril/Valsartan therapy in HFrEF patients, in addition to its efficacy in reducing mortality and rehospitalisation rate. Methods: We performed a single center, prospective, cohort study of HFrEF patients (n=100) who were treated with Sacubitril/Valsartan for a median duration of 6 months. Clinical and echocardiographic parameters were reviewed at baseline and after 6 months. Results: Among 100 patients (median age, 56.5 years; 76% men), at 6 months, improvement of NYHA class has occurred in 83.9% patients (P < 0.001) and only 16.1% remain unchanged. The median LVEF was 30% and increased to 35% after treatment (P < 0.001), about 51.6% patients showed increase in LVEF at least by 5% and 23.7% showed increase in LVEF at least by 10%. Left ventricular diastolic volume decreased from a median baseline 179 to 150ml (P < 0.001), and left ventricular systolic volume decreased from a median baseline 125 to 91ml (P <0.001). About 84 (84%) patients were hospitalized before starting the treatment, and only 33 (35.9%) patients were rehospitalized after initiating the treatment during the follow up period (P=.007).The most frequent adverse events were hypotension (7.5%), hyperkalemia (7.5%), and worsening kidney function 6.5% |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Heart failure with reduced ejection fraction (HFrEF) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | LVEF |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sacubitril / Valsartan |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Shehata Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Abdelhamid Abdelaziz , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Abdelmeguid Mahdy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.04.M.Sc.2019.Mo.S | 01010110080934000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.04.M.Sc.2019.Mo.S | 01020110080934000 | 22.09.2023 | CD - Rom | 80934.CD |