Clinico-pharmacological study of low dose capecitabine and oxaliplatin versus standard XELOX in metastatic colorectal cancer / (Record no. 76870)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02813cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200307s2020 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.04.Ph.D.2020.Ra.C |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Raghda Yahia Abuelela |
| 245 10 - TITLE STATEMENT | |
| Title | Clinico-pharmacological study of low dose capecitabine and oxaliplatin versus standard XELOX in metastatic colorectal cancer / |
| Statement of responsibility, etc. | Raghda Yahia Abuelela ; Supervised Mostafa Mahmoud Elserafi , Samia Abdelsamee Shouman , Maha Yahia Ismail |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | في علاج أورام القولون والمستقيم المتقدمه XELOXدراسه فارما إكلينيكيه لمقارنه إستخدام الكابسيتبين والأوكسالبلاتين بجرعات منخفضه وإستخدام برتوكول |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Raghda Yahia Abuelela , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 178 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Oncology (Medical) |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Colorectal cancer (CRC) is the fourth most common human malignancy, and the leading cause of cancer related deaths worldwide. Conventional chemotherapy is normally administered near the maximal tolerated dose while metronomic chemotherapy refers to more frequent administration of chemotherapeutics at doses significantly less than the maximum tolerated dose, with no prolonged drug-free breaks Aims: To compare between low dose metronomic chemotherapy with Capecitabine and Oxaliplatin is and classic XELOX in treatment of metastatic Colorectal cancer regarding response rates, toxicity and pharmacokinetics. Methods:This is a randomized phase II prospective cohort study that included 70 metastatic colo-rectal cancer patients diagnosed at National Cancer Institute (NCI), Cairo University between January 2016 and June 2017. Results: The median duration of the treatment for each arm was 6 months.Toxicity occurred in 26 cases (75 % of arm A) and 21 cases (60% of arm B), The median TTP for patients receiving arm A was 7.6 months while the patients receiving arm B had median TTP 5.7 months (P=0.318) while the median OS for Arm A 15.9 and for Arm B (15.8) (p=0.8) that is insignificant.Conclusion: Metronomic protocol was associated with lower rates of toxicity, better pharmacokinetics profile without improvements in PFS or OS |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chemotherapy |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colo-rectal cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Low dose metronomic |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Maha Yahia Ismail , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Mahmoud Elserafi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia Abdelsamee Shouman , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.04.Ph.D.2020.Ra.C | 01010110080979000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.04.Ph.D.2020.Ra.C | 01020110080979000 | 22.09.2023 | CD - Rom | 80979.CD |