Study associationof microRNA-326ex pressionwith plasma adiponectinindiabetic patients / (Record no. 77045)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03182cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032536.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200728s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.Ph.D.2019.Kh.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Khadiga Mahmoud Mostafa |
| 245 10 - TITLE STATEMENT | |
| Title | Study associationof microRNA-326ex pressionwith plasma adiponectinindiabetic patients / |
| Statement of responsibility, etc. | Khadiga Mahmoud Mostafa ; Supervised Dina Sabry , Ghada Mahmoud Abdelaziz , Randa Fayez Salama |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة العلاقة بين التعبير الجينى للحمض النووى الريبوزى متناهى الصغر 326 وبلازما الأديبونيكتين فى مرضى السكر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Khadiga Mahmoud Mostafa , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: MiRNAs has a role in physiological processes, including cell proliferation, differentiation, apoptosis and metabolism consequently their dysregulation appears to be involved in various disorders, including metabolic diseases such as diabetes. Adiponectin is the most abundant peptide hormone secreted by adipocytes. It has become a biomarker for obesity-related diseases as metabolic syndrome, type 2 Diabetes mellitus, and cardiovascular disease.Aim of the work: The aim of this work was to assess correlation between exosomal miRNA 326 and adiponectin in diapetic patients.Subjects and Methods: One hundred diabetic patients and fifty healthy subjects were included in the study. They were classified into three groups: Group (I): Fifty apparently healthy volunteers as control subjects. Group (II): Fifty patients with type I diabetes. Group (III): Fifty patients with type II diabetes. MiRNA was extracted from isolated exosomes samples of both the diseased and control groups . MiRNA 326 quantitative gene expression was assessed by real-time polymerase chain reaction. Adiponectin and Insulin were assessed by ELISA. Correlation between miRNA326 gene expression and adiponectin level was analysed statistically.Results: There was significant increase in HOMA level in type II diabetics compared to control subjects and type I diabetic patients. Severe insulin resistance was most significantly occurring in type II diabetes, significant increase in miRNA 326 expression in type I and type II diabetic patients compared to control subjects, significant decrease in adiponectin level in type I and type II diabetic patients compared to control subjects and significant decrease in adiponectin level in type II diabetes patients when compared to type I diabetic patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetes |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiR-326 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Sabry , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mahmoud Abdelaziz , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Randa Fayez Salama , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.Ph.D.2019.Kh.S | 01010110081102000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.Ph.D.2019.Kh.S | 01020110081102000 | 22.09.2023 | CD - Rom | 81102.CD |