MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02520cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
200811s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.08.M.Sc.2020.Sh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Shaymaa Mohamed Elhady Ahmed |
| 245 12 - TITLE STATEMENT |
|---|
| Title |
A pharmaceutical study on a colon targeted drug delivery system / |
| Statement of responsibility, etc. |
Shaymaa Mohamed Elhady Ahmed ; Supervised Omaima Naim Elgazayerly , Manal Mohy Eldin Elashmoony , Mohamed Hassan Hany Kamel Hassan Aboughaly |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة صيدلية على أحد الأنظمة الموجهة للقولون |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Shaymaa Mohamed Elhady Ahmed , |
| Date of publication, distribution, etc. |
2020 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
179 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacrutics |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
One of the challenges facing formulation scientists is the development of site specific delivery systems capable of releasing the active ingredient in the lower part of the small intestine and/or colon. Development of colon specific drug delivery systems can enhance the treatment of colonic conditions such as ulcerative colitis (UC), Crohn's disease (CD) and colorectal cancer (CRC). Colon targeted drug delivery systems (CTDDS)have the potential to reduce side effects and increase pharmacological response with low drug concentration. Recent studies proved the efficiency of celecoxib (CXB) for the treatment of inflammatory bowel diseases (IBD). CXB is a selective cyclooxygenase (COX)-2 inhibitor used as a non-steroidal anti-inflammatory drug with less gastrointestinal side effects compared to non-selective COX inhibitors. However, COX-2 inhibitors promote thrombosis and substantially increase the risk of heart attack at high doses after systemic administration.Being a Biopharmaceutical classification system (BCS) class II drug, it suffers from poor bioavailability (22-40%) caused by its low water solubility (3.3 æg/mL). Due to the colon low fluid volume, it will be more difficult to dissolve CXB in the colon |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Celecoxib |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Freeze drying |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Nano-mixed micelles |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Manal Mohy Eldin Elashmoony , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Hassan Hany Kamel Hassan Aboughaly , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Omaima Naim Elgazayerly , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
