Alterations in some genetic expression in relation to gold nanoparticles application / (Record no. 77211)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02686cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032541.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200816s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.04.Ph.D.2020.Gh.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ghada Ali Abdallah |
| 245 10 - TITLE STATEMENT | |
| Title | Alterations in some genetic expression in relation to gold nanoparticles application / |
| Statement of responsibility, etc. | Ghada Ali Abdallah ; Supervised Said Z. M. Moussa , Hassan A.Amer , Marwa I. Abdelhamid |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التغيرات فى بعض التعبيرات الجينية نتيجة استخدام جزيئات الذهب متناهية الصغر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ghada Ali Abdallah , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 148 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Biochemistry and Chemistry of Nutrition |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Gold nanoparticles (AuNPs) have been considered as an ideal candidate in various biomedical applications due to their ease of tailoring into different size, shape, and decorations with different functionalities. The current study was conducted to investigate (both in vitro and in vivo) some of the genetic and epigenetic alterations in lung cells in response to the exposure to AuNPs. Forty Wister rats were divided into two equal groups, control group and AuNPs-treated group received a single intravenous (IV) injection of citrate-capped spherical AuNPs (25 ± 3 nm) at a final dose of 0.015 mg /kg body wt. Lung samples were then collected from both groups at one day, one week, one month and two months post-injection. The in vitro experiment involves the treatment of human lung fibroblast cells (WI-38) with the same AuNPs sphere at a final concentration of 2 nM for 24, 48, 72 and 96 h. Transmission electron microscopy (TEM) and energy-dispersive X-ray (EDX) spectroscopy verified both the in vivo and in vitro cellular uptake of AuNPs into the cytoplasm at the ultrastructural level.The in vitro effect of AuNPs on cell viability was investigated by MTT assay. The molecular modifications caused by AuNPs exposure at level of expression of microRNA-155 (miR-155) were analyzed byTaqMan®qRT-PCR |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Epigenetic |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gold Nanoparticles (AuNPs) |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA-155 (MiR-155) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hassan A.Amer , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa I. Abdelhamid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Said Z. M. Moussa , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.04.Ph.D.2020.Gh.A | 01010110081198000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.04.Ph.D.2020.Gh.A | 01020110081198000 | 22.09.2023 | CD - Rom | 81198.CD |