Pharmacological study on the combined effect of tamoxifen and simvastatin on breast cancer cell lines / (Record no. 77268)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03006cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032543.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200818s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Am.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amel Belgasem Ibrahim |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacological study on the combined effect of tamoxifen and simvastatin on breast cancer cell lines / |
| Statement of responsibility, etc. | Amel Belgasem Ibrahim ; Supervised Hala F. Zaki , Samia A. Shouman , Walaa W. Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة دوائية للتأثير المشترك للتاموكسيفين وسيمفاستاتين فى خطوط خلايا سرطان الثدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amel Belgasem Ibrahim , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 181 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Tamoxifen (TAM) is the gold-standard drug therapy for estrogen receptor-positive (ER+) breast cancer, however, its resistance is a challenging in clinical practice. Simvastatin (SIM) is a lipid-lowering agent and has been shown to inhibit several types of cancer cells growth. Aim of the work: The study aimed to investigate the combined anticancer effect of TAM and SIM and to explore the mechanistic pathway in the treatment of two ER+ breast cancer cell lines, MCF-7 and T47D, as well as in mice-bearing Ehrlich solid tumor.Methods: Breast cancer cell lines were treated with different concentrations of TAM or/and SIM for 72 hrs. The combined effect of drug interaction was measured using the isobologram equation. For the mechanistic pathways, oxidative stress, apoptosis, angiogenesis, inflammatory and metastasis markers were investigated. Besides, in vivo, tumor volume, oxidative stress, and inflammatory markers were explored.Results: The results of this study showed that using the combination index, the drug interaction was antagonistic in MCF-7 and synergistic in T47D cells. Besides, there was a significant decrease in apoptotic marker caspase-3 activity and non-significant change in Bax/bcl-2 ratio as well as a significant decrease in NF- mB, compared to the TAM-treated group in MCF-7cells. However, significant increases in caspase 3 activity, Bax/bcl-2 ratio and NF-mB in T47D cells by the combination regimen.On the other hand, treatment of two breast cancer lines with the combination of TAM, and SIM significantly inhibited the increase in oxidative stress markers, LDH, and glucose uptake induced by TAM |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cytotoxicity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Simvastatin |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Tamoxifen |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hala F. Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samia A. Shouman , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa W. Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Am.P | 01010110081228000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Am.P | 01020110081228000 | 22.09.2023 | CD - Rom | 81228.CD |