MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03224cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
200818s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.01.Ph.D.2020.He.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Heba Ramadan Ghaiad |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Importance of apoprotein A-I and Sphingosine activity and progression in Egyptian patients : |
| Remainder of title |
association with a number of long non-coding RNAs expression / |
| Statement of responsibility, etc. |
Heba Ramadan Ghaiad ; Supervised Amira A. Shaheen , Maha M. Elsawalhi , Mohammed M. Nooh |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
أهمية صميم البروتين الشحمى أ-{uئإ٨ؤ} و السفينجوزين كيناز في نشاط و تطوّر مرض التصلب المتعدد فى المرضى المصريين : |
| Remainder of title |
إرتباطهما بالتعبير الجينى لعدد من الأحماض النووية الريبوزية الطويلة غير المشفرة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Heba Ramadan Ghaiad , |
| Date of publication, distribution, etc. |
2020 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
111 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Several studies pointed out a possible protective role of apoprotein A1 (ApoA1) in inflammation and autoimmunity, besides the involvement of sphingosine 1-phosphate receptors (S1PRs) in mediating such action of ApoA1. However, the exact regulatory mechanisms of these biomolecules and their involvement in multiple sclerosis (MS) remains to be elucidated. This study investigated the role of ApoA1, sphingosine kinase 1 and 2 (SPHK1 & 2), S1PR1 & 5, interferon-Þ (IFN-Þ) and interleukin 17 (IL17) in MS, besides their regulatory long noncoding RNAs (lncRNA): APOA1-AS, IFNG-AS1, and RMRP. Herein, the expression profiles of SPHKs, S1PRs, and lncRNAs were measured in the blood of 72 relapsing-remitting MS (RRMS) patients (37 during relapse and 35 in remission) and 28 healthy controls using qRT-PCR. Plasma levels of ApoA1, IFN-Þ and IL17 were determined. The impact of these parameters was assessed on MS activity, relapse rate, and patient disability. Moreover, the potential use of these parameters as novel diagnostic and prognostic biomarkers for MS was evaluated. Our study demonstrated upregulation of APOA1-AS, IFNG-AS1, SPHK1 & 2, and S1PR5 in RRMS patients. Moreover, significant differences in ApoA1, SPHK2, and IL17 were observed between patients during relapse and in remission. Importantly, ApoA1, SPHK2, and IL17 were related to MS activity, while S1PR1 and IFN-Þ were linked to patient disability, though, only IFN-Þ was associated with relapse rate. Finally, this study provided evidence for excellent diagnostic power of IFN-Þ, IL17, SPHK1 and lncRNA APOA1-AS for MS, whereas SPHK2 showed the highest prognostic power in predicting MS patients in relapse |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Apoprotein A |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Interferon-Þ |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Multiple sclerosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Amira A. Shaheen , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maha M. Elsawalhi , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohammed M. Nooh , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Shimaa |
| Reviser |
Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
