Development of biodegradable polymeric nanocapsules as a drug delivery system targeting Helicobacter pylori / (Record no. 77292)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02136cam a2200337 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032543.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200819s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.M.Sc.2020.Ay.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aya Mohamed Abdelghany Ahmed |
| 245 10 - TITLE STATEMENT | |
| Title | Development of biodegradable polymeric nanocapsules as a drug delivery system targeting Helicobacter pylori / |
| Statement of responsibility, etc. | Aya Mohamed Abdelghany Ahmed ; Supervised Mohamed Ali Eldesouky ,Mohamed Abbas Shemis |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تطوير كبسولات بوليمارية متناهية الصغر قابلة للتحلل البيولوجى لنقل الدواء الذى يستهدف الميكروب الحلزونى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Aya Mohamed Abdelghany Ahmed , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 95 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In this study we used double emulsion technique to prepare spherical shaped polymeric nanocapsules composed of amoxicillin trihydrate as the core substance and a biodegradabe biocompatible poly ({uF065}-caprolactone) as the shell material. The hydrodynamic diameter of the prepared nanocapsules was 287 ± 8 nm with positive zeta potential. In vitro release study indicated that the polymeric nanocapsules showed the least release at pH 1.2 simulating the gastric fluid while increasing release at pH 7.0 where the H. pylori resides. The in vitro antibacterial assay showed better efficiency for Amoxicillin nanocapsules than the free drug. Cytotoxicity studies showed least cytotoxicity for the polymeric nanocapsules in comparison to the amoxicillin |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Double emulsion |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | H. pylori |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Polymeric nanocapsules |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Abbas Shemis , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali Eldesouky , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.M.Sc.2020.Ay.D | 01010110081254000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.M.Sc.2020.Ay.D | 01020110081254000 | 22.09.2023 | CD - Rom | 81254.CD |