Dysregulation of MicroRNA in adult acute myeloid leukemia / (Record no. 77569)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02950cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032552.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200905s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.03.Ph.D.2019.Ah.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmad Samir Abdelhamid |
| 245 10 - TITLE STATEMENT | |
| Title | Dysregulation of MicroRNA in adult acute myeloid leukemia / |
| Statement of responsibility, etc. | Ahmad Samir Abdelhamid ; Supervised Nayera Hamdy Elshakankiry , Magdy Mohamad Saber Mowad , Ghada Mohamad Elsayed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | اضطراب تنظيم الأحماض النووية الريبوزية المتناهية الصغر فى سرطان الدم الميلودى الحاد فى البالغين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmad Samir Abdelhamid , |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 140 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Introduction: Acute myeloid leukemia (AML) is the most common malignant myeloid disease in adults. Growing evidence has proved that microRNAs(miRNAs) may be a novel class of non-invasive biomarkers that can provide prognostic information in AML. MiR-204 shows drastically reduced expression in several cancers and acts as a potent tumor suppressor, inhibiting tumor metastasis in vivo. Aim of the work: The purpose of the present study is to measure the level of expression of miR-204 in adult denovo AML and to assess the correlation between this level of expression with disease outcome and other prognostic factors. Material and methods: Detection of miR-204 was done using RT-PCR in newly diagnosed AML adult patients and age matched controls. miR-204 was also measured in 16 patients at day 28 after induction of chemotherapy. Results: The study included 87 newly diagnosed AML adult patients (43 males and 44 females, the mean age was 44.4 years), and 7 age matched control. AML patients showed significantly lower miR-204 expression, when compared to control group (p=0.029). Low expression of miR-204 was significantly associated with poor prognosis in AML patients since it associated with shorter OS (p=0.015) and DFS (p=0.008). There was also statistically significant correlation between achieving CR and increased mir-204 expression after treatment (p=0.049). Low miR-204 expression was significantly associated with positive CD34 in AML patients (p=0.017) and, with diabetes mellitus (p=0.014), and with poor performance status (p=0.009) |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Acute myeloid leukemia |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Adult |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MicroRNA |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mohamad Elsayed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Magdy Mohamad Saber Mowad , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nayera Hamdy Elshakankiry , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.03.Ph.D.2019.Ah.D | 01010110081403000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.03.Ph.D.2019.Ah.D | 01020110081403000 | 22.09.2023 | CD - Rom | 81403.CD |