Prognostic significance of suryiyin expression in pediatric ewing sarcoma family of tumors at National Cancer Institute, Egypt / (Record no. 77571)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03170cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032552.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200905s2020 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.19.05.Ph.D.2020.Af.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Afaf Mohammad Mahmoud |
| 245 10 - TITLE STATEMENT | |
| Title | Prognostic significance of suryiyin expression in pediatric ewing sarcoma family of tumors at National Cancer Institute, Egypt / |
| Statement of responsibility, etc. | Afaf Mohammad Mahmoud ; Supervised Lobna Mohamed Shalaby , Wael Zekri Khaled , Eman Naguib Khorshed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | القيمة التنبؤية للسرفيفين فى أورامالايونج ساركوما فى الأطفال بالمعهد القومى للأورام - مصر |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Afaf Mohammad Mahmoud , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 160 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Pediatric Oncology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Survivin is an inhibitor of apoptosis protein that inhibits caspases and blocks cell death. It is undetectable in most normal adult tissues. High survivin expression has been detected in various tumors and has been correlated with therapy resistance and poor outcome. Objectives: We conducted this study to examine survivin expression in pediatric Ewing sarcoma family of tumors (ESFT), and evaluate its role in predicting clinical outcome. Patients and tnahods: Formalin-fixed paraffin-embedded tumor tissues from 108 pediatric patients with ESFT were examined for survivin status and percent of expression by immunostaining with survivin rabbit monoclonal antibodies. The relationship between survivin status and dinico-pathologic characteristics mod survival rates was evaluated. Results: Survival expression was detected in tumor tissues of 72 (66.7 %) patients. High expression (0.50%) was detected in only 18 (16.7%) patients.From all clinico-pathologic factors, positive survivin status was only strongly associated with male gender (p value= 0.041). In the Can proportional regression model analysis, high survivin expression was shown to be a significant univariate parameter for poorer overall (OS) and event free survival (EFS) with p value 0.033, and 0.037 respectively. Also, on multivariate analysis; it was an independent factor that significantly affect the OS (fi 0.041; BR 1.97 with 95% CI of 1.03-3.79), and EFS (p: 0.049; IIR 1.86 with 95% CI of 1.00-346). Conclusion: High expression of survivin in ESFT identifies a group of patients with poor prognosis.This result needs to be confirmed in prospective studies including larger number of patients thus survivin expression may in future help to refute risk adapted treatment |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Ewing Sarcoma |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pediatric |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Survivin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Naguib Khorshed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Lobna Mohamed Shalaby , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wael Zekri Khaled , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.19.05.Ph.D.2020.Af.P | 01010110081402000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.19.05.Ph.D.2020.Af.P | 01020110081402000 | 22.09.2023 | CD - Rom | 81402.CD |