Preparation of transition metal complexes of some psychoactive substances and evaluation of their biological activity / (Record no. 77667)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03099cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032555.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200909s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.09.Ph.D.2020.Ab.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Abanoub Mosaad Abdallah Abdelmonaem |
| 245 10 - TITLE STATEMENT | |
| Title | Preparation of transition metal complexes of some psychoactive substances and evaluation of their biological activity / |
| Statement of responsibility, etc. | Abanoub Mosaad Abdallah Abdelmonaem ; Supervised Gehad Genidy Mohamed Genidy , Nadia G. Zaki , Walaa Hamed Mahmoud |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تحضير متراكبات لعناصر انتقالية لبعض المواد المؤثرة على الحالة النفسية وتقييم نشاطها البيولوجى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Abanoub Mosaad Abdallah Abdelmonaem , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 191 P. : |
| Other physical details | charts , facimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Inorganic Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Twenty-two new binary and mixed-ligand transition metal complexes of cocaine and TMEDA (as a secondary ligand) with some d- and f-block transition metal elements were synthesized as new potent anticancer metal-based agents against human liver HepG-2 and breast MCF-7 cancer cells. The prepared complexes were structurally characterized by a variety of physicochemical tools such as elemental analysis, FT-IR, UV-vis, mass spectroscopy, scanning electron microscope (SEM),molar conductance, and thermal analyses techniques.Structural, spectroscopic, electronic, and thermodynamic properties were also studied theoretically by performing density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations for the purpose of correlating between the experimental and theoretical results.The newly synthesized complexes were also investigatedfor their antiproliferative activityagainst HepG-2 and MCF-7 cancer cell lines.Further, in vitro testing was carried out to study their antimetastatic properties, apoptosis inducing characteristics, effect on tumor suppressor proteins(P21 and P27) level and effect on glutathione peroxidase (GPx) level in MCF-7 cells.In addition, the antimicrobial activities of the formed metal complexes were studied in terms of their antibacterial activities against Staphylococcus aureus and Bacillus subtilisas Gram positive bacteriaand Salmonella typhimurium and Escherichia colias Gram negative bacteria comparing to gentamycin and their antifungal activities towards Aspergillusfumigatusand Candida albicanscomparing to ketoconazole using the agar well-diffusion technique |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cocaine |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TMEDA |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Transition metal complexes |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gehad Genidy Mohamed Genid , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia G. Zaki , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Walaa Hamed Mahmoud , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.09.Ph.D.2020.Ab.P | 01010110081473000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.09.Ph.D.2020.Ab.P | 01020110081473000 | 22.09.2023 | CD - Rom | 81473.CD |