Bleomycin-induced lung fibrosis in carnitine-deficient rats : (Record no. 77735)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03287cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032557.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200914s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.En.B |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Enas Sayed Mohamed Gad Elrab |
| 245 10 - TITLE STATEMENT | |
| Title | Bleomycin-induced lung fibrosis in carnitine-deficient rats : |
| Remainder of title | Therapeutic interplay of mesenchymal stem cells and tyrosine kinase inhibition / |
| Statement of responsibility, etc. | Enas Sayed Mohamed Gad Elrab ; Supervised Mahmoud M. Khattab , Rania M. Abdelsalam , Hossam M. Arafa |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تليف الرئة المحدث بواسطة البليوميسين فى حالة نقص الكارنتين فى الجرذان : |
| Remainder of title | التفاعل العلاجى لخلايا اللُحمة المتوسطة الجزعية مع كبح التيروزين كيناز |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Enas Sayed Mohamed Gad Elrab , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 228 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive lung damage. A murine lung fibrosis model was developed by intra-tracheal instillation of bleomycin (BLM) (5 mg/kg, Once). Induction of lung fibrosis was characterized by means of pulmonary function assessment, serological assay of pro-inflammatory cytokines, histological scoring and collagen deposition, immuno-histochemical localization of IL-6 and TNF-Ü and RT-PCR quantification of pro-fibrotic growth factors; TGF-Ý, Ü-SMA, EGF-Ý and SMAD-3. BLM induced marked disruptions in all these aforementioned parameters. One of the current study aims was to evaluate the therapeutic effect of the combined therapy of the tyrosine kinase inhibitor, nintedanib (100 mg/kg, IP, Once daily, for 28 days)and Bone marrow-mesenchymal stem cells (BM-MSCs) (1{u00D7}106 cells/1ml/rat) on retraction of lung fibrosis in bleomycin treated rats.Treatment with either nintedanib or MSCs had almost the same beneficial effects in this traditional lung fibrosis model.The combination modality that incorporated both treatment options has proven therapeutic efficacy that outperformed either treatment given alone.A combined model was developed following administration of BLM and MD in an attempt to address as to whether or not carnitine deficiency would exacerbate the injurious effects of BLM on lung tissue.Interestingly, not only carnitine deficiency added to the detrimental toxic effects of BLM in lung tissue, but also BLM per se resulted in a sort of carnitine nadir.To resolve such paradox, one could argue that carnitine deficiency could possibly be a potential risk factor for inducing lung fibrosis |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Carnitine-deficient rats |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Chronic lung disease |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Idiopathic pulmonary fibrosis (IPF) |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hossam M. Arafa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mahmoud M. Khattab , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania M. Abdelsalam , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.En.B | 01010110081536000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.En.B | 01020110081536000 | 22.09.2023 | CD - Rom | 81536.CD |