Study of possible anti-ulcerognic potential of cilostazol and gymnema sylvester extract on gastric ulcer in rats / (Record no. 77991)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03046cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032606.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200930s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2020.Mo.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohammed Abdulrahman Mohammed Alkhawlani |
| 245 10 - TITLE STATEMENT | |
| Title | Study of possible anti-ulcerognic potential of cilostazol and gymnema sylvester extract on gastric ulcer in rats / |
| Statement of responsibility, etc. | Mohammed Abdulrahman Mohammed Alkhawlani ; Supervised Helmy M. Sayed Ahmed , Wafaa I. Eleraky , Nada Sallam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة القدرة المضادة للتقرح المحتملة لسيلوستازول و خلاصة نبات الساجدة (جمنيما سيلفستر) على قرحة المعدة فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Mohammed Abdulrahman Mohammed Alkhawlani , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135 P . : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The aim of this work is to investigate the potential gastroprotective effect of a specific phosphodiesterase 3 inhibitor namely cilostazole (5 or 10 mg/kg, p.o.) and plant product namely G. sylvestre (200 or 400 mg/kg, p.o.) either singly or in combination in comparison with the standard antiulcer ranitidine (50 mg/kg, p.o.) on peptic ulcer induced by either ethanol or pyloric ligation in male adult albino rats. Gastric mucosa was examined macroscopically, histologically, and biochemically for ulcer severity, markers of oxidative stress, proinflammatory cytokines, apoptotic, and cytoprotective mediators. Gastric acidic output, peptic activity, and mucin content were measured in gastric fluids. Pretreatment with cilostazol or G. sylvestre reduced ulcer number and severity, ameliorated redox status (reduced glutathione and malonaldehyde content), and decreased levels of IL-1Ý, IL-6, and TNF- in gastric mucosa, in parallel with increases in mucosal defensive factors nitric oxide (NO), prostaglandin E2 (PGE2), and heat-shock protein 70 (HSP70) promoting mucus secretion, tissue perfusion, and regeneration. In addition, G. sylvestre reduced gastric acid secretion while no such changes were observed by cilostazol. The gastroprotective effect of cilostazol may be related to an increase of the cAMP content in mucous cells via inhibition of PDE 3, while G. sylvestre effects may be attributed to its constituent as triterpenes, flavonoids, glycosides and anthroquinones. The results showed also that the combined use of cilostazol and G |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cilostazol |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gastric ulcer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Gymnema Sylvestre |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Helmy M. Sayed Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada Sallam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wafaa I. Eleraky , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2020.Mo.S | 01010110081579000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.09.Ph.D.2020.Mo.S | 01020110081579000 | 22.09.2023 | CD - Rom | 81579.CD |