MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02713cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
201001s2019 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.12.21.M.Sc.2019.Ra.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Razan Mohammed Hassan Mohammed |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Assessment of the antitumor efficacy of annona muricata (Graviola) in breast and prostate human cancer cell lines / |
| Statement of responsibility, etc. |
Razan Mohammed Hassan Mohammed ; Supervised Magda Mohamed Noshy , Hanan Ramadan Hamad |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تقييم الفاعليه المضادة للأورام لأنونا ميركاتا (غرافيولا) فى خطوط خلايا سرطان الثدى والبروستاتا البشرية |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Razan Mohammed Hassan Mohammed , |
| Date of publication, distribution, etc. |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
77 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Background Graviola (Annona muricata) is a small tropical evergreen fruit tree that is widely grown in many tropical zones and used as traditional medicine to treat cancer and tumors. Graviola has been reported to be effective against various human tumors in vitro cultures. Although the underlying molecular mechanisms of its antitumor efficacy are not fully understood, it has been suggested that the induction of apoptosis in cancer cells may account for Graviola antitumor efficacy. Aim The present study aimed to investigate the antitumor efficacy of Graviola leaves extract and to explore its effect on the expression levels of certain apoptotic genes (P53, Bax and Bcl-2) in human breast cancer cell line (MCF-7) and human prostate cancer cell line (PC3). Since the DNA damage is likely to be the primary cause of apoptosis, this study also aimed to evaluate the potential of Graviola leaves extract to induce DNA damage in both human cancer cells. Materials and methods The anti-proliferative effect of the methanol extract of Graviola leaves was evaluated by neutral red uptake assay. Gene expression was assayed by using quantitative real time polymerase chain reaction (qRT-PCR) while DNA damage was estimated by using alkaline comet assay. Results The results revealed the cytotoxic potential of Graviola leaves extract against the studied human breast and prostate cancer cell lines |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Annona muricata (Graviola) |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Breast |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Prostate human cancer |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Hanan Ramadan Hamad , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Magda Mohamed Noshy , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Amira |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
