Anticancer activity of endophytic fungal extracts in combination with annona muricata (graviola) extracts / (Record no. 78085)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03235cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201005s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.05.Ph.D.2020.Sa.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sara Sayed Ahmed Eltanany |
| 245 10 - TITLE STATEMENT | |
| Title | Anticancer activity of endophytic fungal extracts in combination with annona muricata (graviola) extracts / |
| Statement of responsibility, etc. | Sara Sayed Ahmed Eltanany ; Supervised Tahany Mohamed A. Abdelrahman , Amal Saad Hussein , Safia Beshir Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التأثير المضاد للسرطان لمستخرجات الفطريات الداخلية بالاتحاد مع مستخلصات الانونا ميوريكاتا - نبات القشطة |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Sara Sayed Ahmed Eltanany , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 187 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Botany and Microbiology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cancer is a major cause of mortality however advances in surgery and therapy. Plants such as Annona muricata have played in the treatment of cancer and infectious diseases. Screening of the endophytic fungi associated with Annona plant parts indicated that a total of sixty five endophytic fungal isolates were isolated. Molecular identification done for A. niger isolate (2), the most frequent species, revealed that it is A. niger strain SH3 using 18S rDNA and phylogenetic analysis.It has accession number of MG847141.1 in (https://www.ncbi.nlm.nih.gov/nuccore/MG847141)GenBank. Phytochemical analysis were tested for different Annona parts along with the isolated endophytic fungi and indicated the occurrence of alkaloids, flavonoids, terpenoids, phenols, proteins and anthraquinone. In vitro cytotoxicity assay of the endophytic fungal extracts in addition to seed, leaves and fruit extracts was done against human cell lines of breast cancer (MDA-MB-231), cell lines of colon cancer (Caco2) and liver cancer (HepG-2) using MTT assay method and indicated the effectiveness of R. solani, P. jensenii, A. niger, A. niger Strain SH3 and seed extracts specifically against Caco2 cancer cell line. Gas Chromatography Mass Spectroscopy (GC-MS) was used for analysis of extracts which showed the most cytotoxic activity in In vitro study which showed that alkaloids, terpenoids and phenolic compounds are dominant in fungal extracts while fatty acids are dominant in Annona seed extract. Combination study using Compusyn software between the most effective anticancer endophytic fungal strain A. niger strain SH3 extract with A.muricata seed extract against liver cancer cell line (HepG2) showed antagonistic activity between both of them while the same combination study against colon cancer cell line(Caco2) showed synergistic activity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Annona muricata |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Antimicrobial activity |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Endopytic Fungi |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Saad Hussein , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Safia Beshir Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tahany Mohamed A. Abdelrahman , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.05.Ph.D.2020.Sa.A | 01010110081636000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.05.Ph.D.2020.Sa.A | 01020110081636000 | 22.09.2023 | CD - Rom | 81636.CD |