MiRNA-22 and its relation to serum level of vitamin D and vitamin D receptor in patients with multiple sclerosis / (Record no. 78283)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02805cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032615.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201018s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.03.M.Sc.2020.Ah.M |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Mohamed Bahaa Eldin Khedr |
| 245 10 - TITLE STATEMENT | |
| Title | MiRNA-22 and its relation to serum level of vitamin D and vitamin D receptor in patients with multiple sclerosis / |
| Statement of responsibility, etc. | Ahmed Mohamed Bahaa Eldin Khedr ; Supervised Olfat Gamil Shaker , Amr Hassan , Taha Abdelrazik Azouz |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | ميكرو إن إيه -22 وعلاقته بمستوى كلاً من فيتامين (د) ومستقبلات فيتامين (د) في مصل الدم في مرضى التصلب المتعدد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Ahmed Mohamed Bahaa Eldin Khedr , |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 139 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background and aims: Micro-RNAs (MiRNAs) were believed to play a role in the pathogenesis of many neurological disorders. We investigated the expression of miRNA-22, vitamin D and vitamin D receptor levels in patients with multiple sclerosis (MS) to clarify their role in MS pathogenesis and their impact on clinical course of the disease (progression and disability). Methods: This case-control study was conducted on 100 subjects; 50 patients with MS fulfilling the 2010 McDonald's criteria and 50 healthy ages and sex matched control. The clinical disability was evaluated using the expanded disability status scale (EDSS). MiRNA-22 expression was performed using Quantitative RT-PCR. Serum level of vitamin D and vitamin D receptor were performed using ELISA techniques. Results: Our results demonstrated that the miRNA-22 was significantly downregulated in MS patients with p-value 0.001. The serum expression of Vit D and VDR were significantly downregulated in MS patients with p-value 0.001. Conclusion: This study suggests the possible role of low serum Vit D as well as serum expression of both miRNA-22 and VDR in MS pathogenesis. Suggesting a possible role of Vit D supplementation in treatment of MS. Further studies are required to clarify the molecular pathways through which miRNA-22 may influence MS pathogenesis and clinical presentation |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MiRNA-22 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Multiple sclerosis |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Vitamin D |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amr Hassan , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Taha Abdelrazik Azouz , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Shimaa |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.03.M.Sc.2020.Ah.M | 01010110081760000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.03.M.Sc.2020.Ah.M | 01020110081760000 | 22.09.2023 | CD - Rom | 81760.CD |