The potential role of adipose tissue-derived mediators as promoters for breast cancer progression / (Record no. 78498)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03039cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223032622.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201101s2020 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2020.Ay.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Aya Saber Ibrahim Imam |
| 245 14 - TITLE STATEMENT | |
| Title | The potential role of adipose tissue-derived mediators as promoters for breast cancer progression / |
| Statement of responsibility, etc. | Aya Saber Ibrahim Imam ; Supervised Mona Mostafa Mohamed , Sherif Abdelaziz Ibrahim , Mohamed Elsayed Elshinawi |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المحتمل لمشتقات وسائط الانسجة الدهنية كمحفزات لتفاقم سرطان الثدى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Aya Saber Ibrahim Imam, |
| Date of publication, distribution, etc. | 2020 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 139 P . : |
| Other physical details | charts , facsmilies ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | nflammatory breast cancer (IBC) represents a deadly aggressive subtype of BC with unique clinical and pathological characteristics. Although hundreds of studies identified different molecular and cellular factors involved in IBC progression, the role of adipocytes is still not elucidated yet. The adipose tissue (AT) expresses a variety of adipokines, which contribute in tumorigenesis. All types of cancer including BC contain a unique sub-population of cells with specific properties that are responsible for maintaining tumor growth and relapse termed cancer stem cells (CSCs). A total of 44 women (13 IBC and 31 non-IBC) diagnosed with BC were enrolled in this study. Herein, the main aim of the present study was to establish ex-vivo model of AT rather than 2D model. Besides, characterize the prominent AT secreted cytokines, chemokines and growth factors in obese IBC vis-à-vis obese non-IBC patients using human cytokine antibody array. Furthermore, our study validated whether the predominant cytokines level is also elevated at the transcript level after explant culture employing quantitative PCR (qPCR). Importantly, we studied the impact of AT secretome on the expression of epithelial-mesenchymal transition markers such as Vimentin and E-cadherin as well as cancer stem cell markers including, CD24 and CD44 in MDA-MB-231 non-IBC and SUM-149 IBC cell lines using qPCR. Data were statistically analyzed using unpaired Student{u2019}s t-test. Our cytokine array results revealed that an overall significantly higher level of a panel of 28 cytokines secreted by AT of obese IBC when compared to that of obese non-IBC patients IBC patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Adipose Tissue |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Breast Cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Interleukin- 6 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Elsayed Elshinaw , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona Mostafa Mohamed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sherif Abdelaziz Ibrahim , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Amira |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2020.Ay.P | 01010110081914000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.21.M.Sc.2020.Ay.P | 01020110081914000 | 22.09.2023 | CD - Rom | 81914.CD |